利多氟嗪
利多氟嗪结构式
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常用名 | 利多氟嗪 | 英文名 | Lidoflazine |
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| CAS号 | 3416-26-0 | 分子量 | 491.61500 | |
| 密度 | 1.161g/cm3 | 沸点 | 632.6ºC at 760mmHg | |
| 分子式 | C30H35F2N3O | 熔点 | 158-162ºC | |
| MSDS | 中文版 美版 | 闪点 | 336.4ºC |
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Protective effects of the lazaroid U74500A and lidoflazine on liver preservation with UW solution.
Transpl. Int. 6(5) , 281-4, (1993) The effect of adding a 21-aminosteroid, U74500A, and a Ca2+ antagonist, lidoflazine, alone and together to UW solution was assessed in a rat liver preservation model. Following preservation, the livers were reperfused using a closed circuit, and the release o... |
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Simpson's paradox and clinical trials: what you find is not necessarily what you prove.
Ann. Emerg. Med. 21(12) , 1480-2, (1992) Expensive clinical trials have become the gold standard for evaluating the efficacy of promising new therapeutic agents. Full exploration of the collected data is routine to maximize the yield of the information available. However, potential methodologic flaw... |
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1,4-Dihydropyridines bearing a pharmacophoric fragment of lidoflazine.
Bioorg. Med. Chem. 4(10) , 1629-35, (1996) A series of 1,4-dihydropyridines bearing a pharmacophoric fragment of lidoflazine was synthesized. The compounds were evaluated for inotropic, chronotropic, and calcium antagonist activities. All compounds behave as inotropic and chronotropic agents, except f... |
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Effects of lidoflazine on left ventricular function in patients.
J. Cardiothorac. Vasc. Anesth. 11(1) , 42-8, (1997) The present study evaluated the effects of the nucleoside transport inhibitor, lidoflazine, at a dose of 1 mg/kg, on left ventricular function.Patients were randomly assigned to receive either lidoflazine or saline in a double-blind manner.A university hospit... |
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The pathophysiology of angina pectoris and the effect of lidoflazine.
Circulation 65(1 Pt 2) , I27-32, (1982) Angina pectoris results from a deficiency in myocardial oxygen supply. The rate-pressure product is an important predictor of myocardial oxygen requirements in patients with ischemic heart disease and in normal persons. The rate-pressure product at the onset ... |
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Lidoflazine and myocardial protection.
J. Thorac. Cardiovasc. Surg. 109(5) , 1013-4; discussion 1015, (1995)
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Protection of human, rat, and guinea-pig atrial muscle by mioflazine, lidoflazine, and verapamil against the destructive effects of high concentrations of Ca2+.
Cardiovasc. Drugs Ther. 6(1) , 47-58, (1992) In right atrial trabeculae from humans and in left atria from rat and guinea-pig hearts, the protective effects of mioflazine, lidoflazine, and verapamil against the accumulation of cellular calcium were investigated. Two consecutive, cumulative increases in ... |
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K(+)-stimulated 45Ca2+ flux into rat neocortical mini-slices is blocked by omega-Aga-IVA and the dual Na+/Ca2+ channel blockers lidoflazine and flunarizine.
Neurosci. Lett. 158(1) , 97-100, (1993) High-threshold neuronal voltage-sensitive Ca2+ channels (VSCCs) have been classified into at least three subtypes, including L, N, and P, based on biophysical and pharmacological criteria. We examined K(+)-induced 45Ca2+ flux into rat neocortical mini-slices ... |
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Nucleoside transport inhibition mediates lidoflazine-induced cardioprotection during intermittent aortic crossclamping.
J. Thorac. Cardiovasc. Surg. 104(6) , 1602-9, (1992) The effects of pretreatment with the nucleoside transport inhibitor lidoflazine on repeated ischemia-reperfusion injury induced by normothermic intermittent aortic crossclamping were studied in canine hearts. Eighteen mongrel dogs were allocated to three grou... |
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Lidoflazine combined with nucleotide precursors increases ATP content and adenosine production in cardiomyocytes.
Nucleosides Nucleotides Nucleic Acids 24(4) , 279-82, (2005) We have previously identified that the nucleoside transport blocker dipyridamole increases adenosine production but may cause depletion of the nucleotide pool in cardiomyocytes during extended exposure and that this effect was abolished by co-administration o... |