醋酸诺美孕酮
醋酸诺美孕酮结构式
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常用名 | 醋酸诺美孕酮 | 英文名 | Nomegestrol acetate |
|---|---|---|---|---|
| CAS号 | 58652-20-3 | 分子量 | 370.482 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 507.3±50.0 °C at 760 mmHg | |
| 分子式 | C23H30O4 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 219.8±30.2 °C | |
| 符号 |
GHS08, GHS09 |
信号词 | Warning |
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Changing convention in combination oral contraceptives: estradiol and nomegestrol acetate in a monophasic 24/4 regimen.
J. Fam. Plann. Reprod. Health Care 39(3) , 211-6, (2013) Initial oral contraceptive regimens were characterised by high doses of ethinylestradiol (EE) and a progestogen in a 21-day regimen that either included seven additional hormone-free tablets or simply the 21 days of combination hormonal tablets. These regimen... |
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A new contraceptive pill containing 17β-estradiol and nomegestrol acetate.
Womens. Health (Lond. Engl.) 9(1) , 13-23, (2013) Most combined oral contraceptive pills contain ethinyl estradiol (EE) with progestins. In order to minimize the pill's cardiovascular risks, the concept of using 17β-estradiol (E2), the endogenous estradiol, arose in the 1970s. Many attempts to develop a pill... |
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The “newer” progestogens and postmenopausal hormone therapy (HRT)
J. Steroid Biochem. Mol. Biol. 142 , 48-51, (2014) • The “newer” progestogens have a high bioavailability. • The “newer” progestogens have a sufficient progestogenic effect. • The “newer” progestogens do not cause undue side effects. • The “newer” progestogens do not jeopardize lipid- and carbohydrate metabol... |
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Comparison of a 24-day and a 21-day pill regimen for the novel combined oral contraceptive, nomegestrol acetate and 17β-estradiol (NOMAC/E2): a double-blind, randomized study.
Hum. Reprod. 26(6) , 1338-47, (2011) BACKGROUND Nomegestrol acetate/17β-estradiol (NOMAC/E(2)) is a new monophasic oral contraceptive combining NOMAC (2.5 mg), a highly selective progesterone-derived progestogen, with E(2) (1.5 mg), which is structurally identical to endogenous estrogen. The obj... |
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Inhibition of ovulation by NOMAC/E2, a novel monophasic oral contraceptive combining nomegestrol acetate and 17β-oestradiol: a double-blind, randomised, dose-finding pilot study.
Eur. J. Contracept. Reprod. Health Care 16(2) , 76-84, (2011) To explore the optimal dose of the progestogen, nomegestrol acetate (NOMAC), required in a monophasic oral contraceptive, in combination with 1.5 mg 17β-oestradiol (E(2)), to inhibit ovulation.A double-blind, randomised study assessing 41 normally cycling wom... |
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Efficacy and tolerability of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-oestradiol in a 24/4 regimen, in comparison to an oral contraceptive containing ethinylestradiol and drospirenone in a 21/7 regimen.
Eur. J. Contracept. Reprod. Health Care 16(6) , 430-43, (2011) The primary objective was to assess the efficacy, cycle control and tolerability of a monophasic combined oral contraceptive (COC) containing nomegestrol acetate (NOMAC) and 17β-oestradiol (E2). Effects on acne were evaluated as a secondary objective. Results... |
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Efficacy, safety, and tolerability of a monophasic oral contraceptive containing nomegestrol acetate and 17β-estradiol: a randomized controlled trial.
Obstet. Gynecol. 119(5) , 989-99, (2012) To estimate the efficacy, cycle control, tolerability, and safety of a monophasic combined oral contraceptive containing nomegestrol acetate and 17β-estradiol (E2) in comparison with drospirenone and ethinyl E2.In a randomized, open-label, comparative multice... |
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[Zoely, a combined oral contraceptive, monophasic pill containing estradiol and nomegestrol acetate].
Rev. Med. Liege. 67(3) , 152-6, (2012) A new combined oral contraceptive called Zoely has just been marketed in Belgium. It contains nomegestrol acetate, a progestin known for its high contraceptive reliability based on its antigonadotropic power and long half-life. This progestin is associated wi... |
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[Nomegestrol acetate: clinical pharmacology].
Minerva Ginecol. 61(5) , 459-63, (2009) Progestogens are used in clinical practice in some conditions. Their effects depend on their chemical structure, pharmacokinetics, pharmacodynamics, with important differences among various progestogens. Generally, progestins are classified according to their... |
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[Actions of a 19-norprogesterone derivative on mammary gland: nomegestrol acetate].
J. Gynecol. Obstet. Biol. Reprod. (Paris.) 34(1 Pt 1) , 69-84, (2005) As the biological effects of progestins vary according to their molecular structure, it becomes essential to differentiate the various types of progestins, particularly with regard to the breast.The purpose of this review was to gather published data on the e... |