盐酸乐卡地平
盐酸乐卡地平结构式
|
常用名 | 盐酸乐卡地平 | 英文名 | Lercanidipine hydrochloride |
|---|---|---|---|---|
| CAS号 | 132866-11-6 | 分子量 | 648.188 | |
| 密度 | N/A | 沸点 | 712.5ºC at 760mmHg | |
| 分子式 | C36H42ClN3O6 | 熔点 | 175-177ºC | |
| MSDS | 中文版 美版 | 闪点 | 384.7ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
|
Differences in lercanidipine systemic exposure when administered according to labelling: in fasting state and 15 minutes before food intake.
Eur. J. Clin. Pharmacol. 68(7) , 1043-7, (2012) The aim of this study was to compare the systemic exposure of lercanidipine (Zanidip) after oral administration in the fasted state and 15 min before food intake (meals) to investigate if the recommendations in the Summary of Product Characteristics (SPC) wit... |
|
|
Rationale for the use of a fixed-dose combination in the management of hypertension: efficacy and tolerability of lercanidipine/enalapril.
Clin. Drug Investig. 30(12) , 843-54, (2010) Hypertension, a significant factor in the development of cerebrovascular disorders, heart disease and renal failure, is a common disorder worldwide. Despite the availability of a wide range of antihypertensive agents, almost two-thirds of hypertensive patient... |
|
|
Lercanidipine rescues hippocampus pyramidal neurons from mild ischemia-induced delayed neuronal death in SHRSP.
Cell. Mol. Neurobiol. 31(4) , 561-7, (2011) Stroke-prone spontaneously hypertensive rats (SHRSPs) are vulnerable to ischemia and delayed neuronal death (DND) of hippocampus pyramidal cells when bilateral carotid arteries are occluded for only 10 min. Since this occlusion induces just mild ischemia, the... |
|
|
Incidence and clinical course of lercanidipine-associated cloudy effluent in continuous ambulatory peritoneal dialysis.
Clin. Nephrol. 74(3) , 217-22, (2010) Lercanidipine, a novel dihydropyridine calcium channel antagonist, has been reported to cause sterile cloudy effluent in patients on continuous ambulatory peritoneal dialysis (CAPD). The purpose of the study was to evaluate the incidence and clinical course o... |
|
|
Polymorphism of the methylenetetrahydrofolate reductase gene C677T and its influence on the antihypertensive and vascular protective effects of short-term lercanidipine treatment.
Gene 500(2) , 207-10, (2012) To determine whether the antihypertensive and vascular protective effects of short-term treatment with lercanidipine, a calcium channel blocker, are modulated by the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism.In a self-controlled study, a ... |
|
|
Efficacy and tolerability of the fixed lercanidipine-enalapril combination in the treatment of patients with essential hypertension.
Arzneimittelforschung 60(3) , 124-30, (2010) The purpose of this first prospective observational cohort study after launch was to document the efficacy and tolerability of therapy with the fixed combination of lercanidipine HCl (CAS 132866-11-6), a third-generation calcium antagonist, and the angiotensi... |
|
|
Drug synergism of antihypertensive action in combination of telmisartan with lercanidipine in spontaneous hypertensive rats.
Arch. Pharm. Res. 33(9) , 1411-8, (2010) To examine drug synergism between angiotensin II AT1-receptor blocker and Ca(2+) channel blocker for lowering blood pressure (BP), telmisartan and lercanidipine were orally injected into to telemetered-spontaneous hypertensive rats and BP was monitored. The h... |
|
|
The solution, solid state stability and kinetic investigation in degradation studies of lercanidipine: study of excipients compatibility of lercanidipine.
Pharm. Dev. Technol. 17(6) , 730-40, (2012) The objectives of this research were to evaluate the stability of lercanidipine in solution state and solid state and explore the compatibility of drug with oils, surfactants and cosurfactants as excipients. The effect of pH on the degradation in solution sta... |
|
|
[Consistence of the radial artery as a conduit used in aortocoronary bypass surgery, a possibility of preventing shunt spasm].
Ter. Arkh. 84(12) , 13-7, (2012) To develop a new procedure to evaluate the functional consistence of the radial artery (RA) as a conduit used in aortocoronary bypass surgery (ACBS), to verify the prognostic value of the changed diameter of RA, and to prevent its spasm.The study enrolled 34 ... |
|
|
[Lercanidipine in the treatment of arterial hypertension].
Kardiologiia 52(12) , 70-4, (2012) This review summarizes data on the effectiveness of lercanidipine. Lercanidipine is dihydropyridine calcium antagonist of the third generation, characterized by high vazoselective, long duration of action and good antihypertensive effect. It may be assigned t... |