烟酸甲酯
烟酸甲酯结构式
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常用名 | 烟酸甲酯 | 英文名 | Methyl nicotinate |
|---|---|---|---|---|
| CAS号 | 93-60-7 | 分子量 | 137.136 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 209.0±0.0 °C at 760 mmHg | |
| 分子式 | C7H7NO2 | 熔点 | 42-44 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 95.6±0.0 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap... |
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Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability.
J. Med. Chem. 49 , 3948-54, (2006) This work was devoted to the search for new artificial membranes allowing a rapid evaluation of passive human skin permeation of compounds with a parallel artificial membrane permeability assay (PAMPA). Effective permeability coefficients (Pe) determined for ... |
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In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities.
J. Med. Chem. 50 , 742-8, (2007) The development of in silico and in vitro tools to estimate or predict the passive human skin permeation and distribution of new chemical entities, useful in dermal drug delivery, in absorption studies of toxic compounds, and in the cosmetics industry, is pre... |
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Influence of the Supramolecular Micro-Assembly of Multiple Emulsions on their Biopharmaceutical Features and In vivo Therapeutic Response.
Curr. Drug Targets 16 , 1612-22, (2015) The ability of some surfactants to self-assemble in a water/oil bi-phase environment thus forming supramolecular structure leading to the formation of w/o/w multiple emulsions was investigated. The w/o/w multiple emulsions obtained by self-assembling (one-ste... |
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The scent ofMycobacterium tuberculosis
Tuberculosis (Edinb.) 88(4) , 317-23, (2008) Worldwide, tuberculosis (TB) kills nearly 2 million people annually, yet rapid diagnosis still relies on a 100-year-old method of sputum staining for acid-fast bacilli. The advent of solid phase micro-extraction and gas chromatography/mass spectrometry makes ... |
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Honeybees Apis mellifera can detect the scent of Mycobacterium tuberculosis.
Tuberculosis (Edinb.) 91(4) , 327-8, (2011) The proboscis extension reflex in honeybees was evaluated for detection of tuberculosis. Restrained bees were tested with methyl phenylacetate, methyl p-anisate, and methyl nicotinate, previously identified from Mycobacterium tuberculosis cultures, to determi... |
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Influence of skin colour on the detection of cutaneous erythema and tanning phenomena using reflectance spectrophotometry.
Skin Res. Technol. 13(3) , 236-41, (2007) This research aims at assessing the influence of baseline skin colour on the ability of reflectance spectrophotometry to detect cutaneous erythema induced by a low concentration of methyl nicotinate (2.5 mM) (first objective), and to detect tanning induced by... |
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Cannabinoids influence lipid-arachidonic acid pathways in schizophrenia.
Biol. Psychiatry 32(10) , 2067-73, (2007) Increasing evidence suggests modulating effects of cannabinoids on time of onset, severity, and outcome of schizophrenia. Efforts to discover the underlying pathomechanism have led to the assumption of gene x environment interactions, including premorbid gene... |
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Determination of the in vivo bioavailability of iontophoretically delivered diclofenac using a methyl nicotinate skin inflammation assay.
Skin Res. Technol. 12(3) , 211-6, (2006) In this study, we investigated the bioavailability of iontophoretically delivered diclofenac with the methylnicotinate (MN) test. The inhibition of an erythema provoked by MN is proportional to the bioavailability of diclofenac in the skin. It was our aim to ... |
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Perturbation of solute transport at a liquid-liquid interface by polyethylene glycol (PEG): implications for PEG-induced biomembrane fusion.
Phys. Chem. Chem. Phys. 13(12) , 5346-52, (2011) The effect of polyethylene glycol 400 (PEG) dissolved at various concentrations (0-40% v/v) in water, on the interfacial transport of methyl nicotinate across an aqueous-isopropyl myristate interface was investigated with a rotating diffusion cell. At four te... |