茶碱
茶碱结构式
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常用名 | 茶碱 | 英文名 | Theophylline |
|---|---|---|---|---|
| CAS号 | 58-55-9 | 分子量 | 180.164 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 454.1±37.0 °C at 760 mmHg | |
| 分子式 | C7H8N4O2 | 熔点 | 271-273 °C | |
| MSDS | 中文版 美版 | 闪点 | 228.4±26.5 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Cytochrome P450-dependent metabolism of caffeine in Drosophila melanogaster.
PLoS ONE 10(2) , e0117328, (2015) Caffeine (1, 3, 7-trimethylxanthine), an alkaloid produced by plants, has antioxidant and insecticide properties that can affect metabolism and cognition. In vertebrates, the metabolites derived from caffeine have been identified, and their functions have bee... |
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Hyperspectral imaging in quality control of inkjet printed personalised dosage forms.
Int. J. Pharm. 483(1-2) , 244-9, (2015) The aim of the study was to investigate applicability of near infra-red (NIR) hyperspectral imaging technique in quality control of printed personalised dosage forms. Inkjet printing technology was utilized to fabricate escalating doses of an active pharmaceu... |
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Ram seminal plasma proteins contribute to sperm capacitation and modulate sperm-zona pellucida interaction.
Theriogenology 83(4) , 670-8, (2015) Incubation of ram spermatozoa in capacitating conditions with cAMP-elevating agents promotes a progressive time-dependent increase in the capacitated sperm subpopulation. In this study, the fertilizing capacity of ram spermatozoa (ability to bind to the zona ... |
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cIEF for rapid pKa determination of small molecules: a proof of concept.
Eur. J. Pharm. Sci. 63 , 14-21, (2014) A capillary isoelectric focusing (cIEF) method was developed for the determination of the ionization constants (pKa) of small molecules. Two approaches used to decrease the electroosmotic flow (EOF) were compared: (i) a hydroxypropylcellulose (HPC) coated cap... |
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Encapsulation of porcine pancreatic islets within an immunoprotective capsule comprising methacrylated glycol chitosan and alginate.
J. Biomed. Mater. Res. B. Appl. Biomater. 103(3) , 503-18, (2015) Encapsulation of cells in biocompatible polymer matrices represents a powerful tool for cell-based therapies and therapeutic delivery systems. This technology has successfully been used to deliver pancreatic islets to humans for the treatment of Type 1 diabet... |
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Xanthine derivatives quantification in serum by capillary zone electrophoresis.
J. Chromatogr. Sci. 52(9) , 1121-6, (2014) A capillary electrophoresis method was developed to quantify caffeine and theophylline, xanthine derivatives with bronchodilator activity. Buffer concentration, pH and applied voltage were optimized using a central composite design-face centred. Separation co... |
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Determination of phytochemicals, antioxidant activity and total phenolic content in Andrographis paniculata using chromatographic methods.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 995-996 , 101-6, (2015) Antioxidant activity, total phenolics content and selected phytochemicals (alkaloids and andrographolides) were determined in Andrographis paniculata and in dietary supplements containing this plant. Antioxidant activity was measured by FRAP, CUPRAC and DPPH ... |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
J. Sci. Ind. Res. 65(10) , 808, (2006) Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be tra... |
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A long Stokes shift red fluorescent Ca2+ indicator protein for two-photon and ratiometric imaging.
Nat. Commun. 5 , 5262, (2014) The introduction of calcium ion (Ca(2+)) indicators based on red fluorescent proteins (RFPs) has created new opportunities for multicolour visualization of intracellular Ca(2+) dynamics. However, one drawback of these indicators is that they have optimal two-... |