丁酸钠
丁酸钠结构式
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常用名 | 丁酸钠 | 英文名 | Sodium butyrate |
|---|---|---|---|---|
| CAS号 | 156-54-7 | 分子量 | 110.087 | |
| 密度 | 0.987g/cm3 | 沸点 | 164.3ºC at 760 mmHg | |
| 分子式 | C4H7NaO2 | 熔点 | 250-253 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 69.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.
PLoS Biol. 12(1) , e1001758, (2014) Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-... |
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Short-chain fatty acids and acidic pH upregulate UT-B, GPR41, and GPR4 in rumen epithelial cells of goats.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 308(4) , R283-93, (2015) Currently, the mechanism(s) responsible for the regulation of urea transporter B (UT-B) expression levels in the epithelium of the rumen remain unclear. We hypothesized that rumen fermentation products affect ruminal UT-B expression. Therefore, the effects of... |
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The PHD finger of p300 influences its ability to acetylate histone and non-histone targets.
J. Mol. Biol. 426(24) , 3960-72, (2014) In enzymes that regulate chromatin structure, the combinatorial occurrence of modules that alter and recognise histone modifications is a recurrent feature. In this study, we explored the functional relationship between the acetyltransferase domain and the ad... |
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SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs.
EMBO J. 33(22) , 2643-58, (2014) Although splicing is essential for the expression of most eukaryotic genes, inactivation of splicing factors causes specific defects in mitosis. The molecular cause of this defect is unknown. Here, we show that the spliceosome subunits SNW1 and PRPF8 are esse... |
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Myocardial mitochondrial dysfunction in mice lacking adiponectin receptor 1.
Basic Res. Cardiol. 110 , 37, (2015) Hypoadiponectinemia is an independent predictor of cardiovascular disease, impairs mitochondrial function in skeletal muscle, and has been linked to the pathogenesis of Type 2 diabetes. In models of Type 2 diabetes, myocardial mitochondrial function is impair... |
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Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation.
Proc. Natl. Acad. Sci. U. S. A. 111(48) , 17116-21, (2014) In the fasted state, increases in catecholamine signaling promote adipocyte function via the protein kinase A-mediated phosphorylation of cyclic AMP response element binding protein (CREB). CREB activity is further up-regulated in obesity, despite reductions ... |
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HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.
Hum. Mol. Genet. 24 , 3257-71, (2015) Huntington's disease (HD) is a fatal neurodegenerative disease, caused by expansion of polyglutamine repeats in the Huntingtin gene, with longer expansions leading to earlier ages of onset. The HD iPSC Consortium has recently reported a new in vitro model of ... |
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G1/S Cell Cycle Checkpoint Dysfunction in Lymphoblasts from Sporadic Parkinson's Disease Patients.
Mol. Neurobiol. 52 , 386-98, (2015) Parkinson's disease (PD) is the second most prevalent neurodegenerative disease among aging individuals, affecting greatly the quality of their life. However, the pathogenesis of Parkinson's disease is still incompletely understood to date. Increasing experim... |
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Effects of dietary sodium butyrate on hepatic biotransformation and pharmacokinetics of erythromycin in chickens.
J. Vet. Pharmacol. Ther. 37(4) , 406-12, (2014) Butyrate, a commonly applied feed additive in poultry nutrition, can modify the expression of certain genes, including those encoding cytochrome P450 (CYP) enzymes. In comparative in vitro and in vivo experiments, the effect of butyrate on hepatic CYP genes w... |
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Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines.
Apoptosis 19(12) , 1769-78, (2014) The apoptosis pathway of programmed cell death is frequently deregulated in cancer. An intact apoptosis pathway is required for proper response to anti-cancer treatment. We investigated the chromatin status of key apoptosis genes in the apoptosis pathway in c... |