5-甲氧基色胺
5-甲氧基色胺结构式
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常用名 | 5-甲氧基色胺 | 英文名 | 5-Methoxy-3-indoleaceate |
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| CAS号 | 608-07-1 | 分子量 | 205.210 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 445.9±30.0 °C at 760 mmHg | |
| 分子式 | C11H14N2O | 熔点 | 245-250 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 223.5±24.6 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Melatonin and its metabolites accumulate in the human epidermis in vivo and inhibit proliferation and tyrosinase activity in epidermal melanocytes in vitro.
Mol. Cell. Endocrinol. 404 , 1-8, (2015) Melatonin and its metabolites including 6-hydroxymelatonin (6(OH)M), N(1)-acetyl-N(2)-formyl-5-methoxykynuramine (AFMK) and 5-methoxytryptamine (5MT) are endogenously produced in human epidermis. This production depends on race, gender and age. The highest me... |
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The antioxidant behaviour of melatonin and structural analogues during lipid peroxidation depends not only on their functional groups but also on the assay system.
Biochem. Biophys. Res. Commun. 423(4) , 873-7, (2012) There is no general agreement yet on the antioxidant effect of pineal indoles against lipid peroxidation. Accordingly, the main goal of the present work was to study the antioxidant activity of melatonin (MLT), N-acetylserotonin (NAS), 5-HO-tryptophan (5HO-TR... |
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Hippocampal serotonin depletion is related to the presence of generalized tonic-clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy.
Epilepsy Res. 111 , 18-25, (2015) Previous studies suggest that concentration of serotonin ([5-HT]) plays a pathogenic role in various types of epilepsy inhibiting seizures. However, most have not considered the clinical variables of epilepsy, and all of these studies included small and heter... |
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Molecular cloning of melatonin 2-hydroxylase responsible for 2-hydroxymelatonin production in rice (Oryza sativa).
J. Pineal Res. 58(3) , 343-51, (2015) Although melatonin biosynthetic genes from plants have been cloned, the melatonin catabolism mechanisms remain unclear. To clone the genes responsible for melatonin metabolism, we ectopically expressed 35 full-length cDNAs of rice 2-oxoglutarate-dependent dio... |
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Biogenic amines modulate pulse rate in the dorsal blood vessel of Lumbriculus variegatus.
Comp. Biochem. Physiol. C. Toxicol. Pharmacol. 151(4) , 467-72, (2010) The biogenic amines are widespread regulators of physiological processes, and play an important role in regulating heart rate in diverse organisms. Here, we present the first pharmacological evidence for a role of the biogenic amines in the regulation of dors... |
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Subjective food hypersensitivity: assessment of enterochromaffin cell markers in blood and gut lavage fluid.
Int. J. Gen. Med. 4 , 555-60, (2011) Food hypersensitivity is commonly suspected, but seldom verified. Patients with subjective food hypersensitivity suffer from both intestinal and extraintestinal health complaints. Abnormalities of the enterochromaffin cells may play a role in the pathogenesis... |
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Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells.
FASEB J. 27(7) , 2742-55, (2013) Indolic and kynuric pathways of skin melatonin metabolism were monitored by liquid chromatography mass spectrometry in human keratinocytes, melanocytes, dermal fibroblasts, and melanoma cells. Production of 6-hydroxymelatonin [6(OH)M], N(1)-acetyl-N(2)-formyl... |
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N-Benzyl-5-methoxytryptamines as Potent Serotonin 5-HT2 Receptor Family Agonists and Comparison with a Series of Phenethylamine Analogues.
ACS Chem. Neurosci. 6 , 1165-75, (2015) A series of N-benzylated-5-methoxytryptamine analogues was prepared and investigated, with special emphasis on substituents in the meta position of the benzyl group. A parallel series of several N-benzylated analogues of 2,5-dimethoxy-4-iodophenethylamine (2C... |
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Inotropic effects of prokinetic agents with 5-HT(4) receptor agonist actions on human isolated myocardial trabeculae.
Life Sci. 90(13-14) , 538-44, (2012) Besides acting as gastrointestinal prokinetic agents, 5-hydroxytryptamine(4) (5-HT(4)) receptor agonists can induce positive inotropism in human isolated atrium, but not in ventricles. We pharmacologically evaluated the gastroprokinetic 5-HT(4) receptor agoni... |
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5-benzyloxytryptamine as an antagonist of TRPM8.
Bioorg. Med. Chem. Lett. 20 , 7076-9, (2010) 5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no anta... |