甲基乙酰亚胺酯 盐酸盐
甲基乙酰亚胺酯 盐酸盐结构式
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常用名 | 甲基乙酰亚胺酯 盐酸盐 | 英文名 | Methyl ethanimidate hydrochloride (1:1) |
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| CAS号 | 14777-27-6 | 分子量 | 109.555 | |
| 密度 | N/A | 沸点 | 24.4ºC at 760mmHg | |
| 分子式 | C3H8ClNO | 熔点 | 105ºC (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 5.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Arginyl residues and thermal stability in proteins.
Mol. Cell Biochem. 71(2) , 121-7, (1986) Guanidination and amidination of bovine serum albumin, yeast enolase and yeast alcohol dehydrogenase were accompanied by increases in thermal stability at lower extents of modification. Decreases in thermal stability result from greater modification. These re... |
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Comparative evaluation of fifteen anti-sickling agents.
Blood 61(4) , 693-704, (1983) Fifteen compounds reported to be inhibitors of gelation or sickling were studied by standard methods. These tests included (1) the determination of the solubility of deoxyhemoglobin S or Csat, (2) evaluation of sickling in whole SS blood at various pO2s, (3) ... |
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Identification of "buried" lysine residues in two variants of chloramphenicol acetyltransferase specified by R-factors.
Biochem. J. 193(2) , 525-39, (1981) Two variants of chloramphenicol acetyltransferase which are specified by genes on plasmids found in Gram-negative bacteria were subjected to amidination with methyl acetimidate to determine the relative reactivity of surface lysine residues and to search for ... |
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Current status of methyl acetimidate as an extracorporeal antisickling agent.
Am. J. Pediatr. Hematol. Oncol. 6(1) , 55-8, (1984) Methyl acetimidate has been shown to be an effective in vitro antisickling agent with few detrimental effects on the red cell. 51Cr-survival of red cells that had been incubated in vitro with methyl acetimidate was prolonged to near normal levels in sickle ce... |
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Protection of erythrocyte membrane amino groups from reaction with methyl acetimidate by pyridoxal 5'-phosphate Schiff base formation.
Biochim. Biophys. Acta 771(2) , 183-7, (1984) Pre-equilibration of erythrocytes with the membrane-impermeable aldehyde, pyridoxal 5'-phosphate, for 30 min at 22 degrees C, prior to the addition of methyl acetimidate to the incubation mixture has been shown to prevent agglutination of acetamidinated cells... |
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Properties of methyl acetimidate and its use as a protein-modifying reagent.
Biochem. J. 193(1) , 245-9, (1981) The rate of hydrolysis of the imido ester methyl acetimidate and its rate of amidination of denatured aldolase were investigated under different conditions of temperature, pH and ionic strength. Both rate constants increase greatly with temperature, whereas i... |
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Cytogenetic evaluations in human lymphocytes exposed to methyl acetimidate, a lysine-specific protein crosslinking agent.
Mutat. Res. 180(1) , 121-9, (1987) The cytogenetic effects of methyl acetimidate (MAI), a lysine-specific protein crosslinking reagent, were investigated using human peripheral lymphocytes in culture. Lymphocytes were treated with the chemical either prior to PHA exposure or 2-3 days following... |
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Rapid removal of acetimidoyl groups from proteins and peptides. Applications to primary structure determination.
Biochem. J. 199(2) , 335-40, (1981) Methylamine buffers can be used for the rapid quantitative removal of acetimidoyl groups from proteins and peptides modified by treatment with ethyl or methyl acetimidate. The half-life for displacement of acetimidoyl groups from fully amidinated proteins inc... |
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Prevention of the immune agglutination of methyl acetimidate-reacted sickle erythrocytes by prior reaction with pyridoxal 5'-phosphate.
J. Biol. Chem. 256(11) , 5324-6, (1981) The appearance of an immune response in some sickle cell anemia patients to reinfused autologous erythrocytes which had been treated with methyl acetimidate (Gabuzda, T. G., Chao, T. L., Berenfeld, M. R., and Gelbart, T. (1980) Blood 56, 1041--1047) was a ser... |
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Differential reactivity of lysine residues of the red blood cell Ca2+ pump involved in the E1-E2 conformational equilibrium.
Biochem. J. 279 ( Pt 1) , 121-7, (1991) 1. Modification of Lys residues of the Ca(2+)-ATPase from human red blood cells with methyl acetimidate (MA) inhibited up to 70% of the Ca(2+)-ATPase activity. Furthermore, calmodulin-activated p-nitrophenyl phosphatase activity was fully inhibited at non-lim... |