双(环戊二烯基)二氯化钼
双(环戊二烯基)二氯化钼结构式
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常用名 | 双(环戊二烯基)二氯化钼 | 英文名 | Molybdocene dichloride |
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| CAS号 | 12184-22-4 | 分子量 | 297.05200 | |
| 密度 | N/A | 沸点 | 41.5ºC at 760mmHg | |
| 分子式 | C10H10Cl2Mo | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Antitumour bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivatives.
Dalton Trans. (32) , 3474-82, (2007) This Perspective will focus on recent developments in the field of antitumour metallocenes structurally related to titanocene dichloride. Despite extensive testing of titanocene dichloride which culminated in phase I and II clinical trials, further trials hav... |
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Coordination chemistry of the antitumor metallocene molybdocene dichloride with biological ligands.
Inorg. Chem. 43(1) , 206-13, (2004) The relative affinity of molybdocene dichloride (Cp(2)MoCl(2)) for the thiol, amino, carboxylate, phosphate(O) and heterocyclic(N) donor ligands present in amino acids and nucleotides, has been studied in aqueous solutions at pH 2-7, using (1)H, (13)C and (31... |
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Organometallic anticancer agents: cellular uptake and cytotoxicity studies on thiol derivatives of the antitumor agent molybdocene dichloride.
J. Med. Chem. 48(6) , 2093-9, (2005) The effect of aqueous solubility, charge, and lability of four thiol derivatives of the antitumor metallocene molybdocene dichloride (Cp(2)MoCl(2)) on the cell uptake and cytotoxicity against V79 Chinese hamster lung cells has been determined. Addition of 4-t... |
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Inclusion complexes of the antitumour metallocenes Cp(2)MCl(2) (M = Mo, Ti) with cucurbit[n]urils.
Dalton Trans. (17) , 2328-34, (2008) The encapsulation of the aquated forms of molybdocene dichloride and titanocene dichloride by cucurbit[n]uril (Q[n], where n = 7 and 8) at different pD values has been studied by (1)H NMR spectroscopy and molecular modelling. (1)H NMR titration experiments in... |
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A (1)H NMR study of the interaction of antitumor metallocenes with glutathione.
J. Inorg. Biochem. 86(2-3) , 611-6, (2001) The interaction of the antitumor active metallocene dihalides Cp(2)MCl(2) (M=Ti, Nb, Mo) and 1 equiv. of glutathione was studied by (1)H NMR spectroscopy at pD 2-7 in 4 mM NaCl solutions. No interaction between glutathione and titanocene dichloride was detect... |
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Genotoxicity and transmission electron microscopy studies of molybdocene dichloride.
J. Inorg. Biochem. 100(7) , 1194-8, (2006) The cytotoxic effects of molybdocene dichloride (Cp(2)MoCl(2)) were investigated in V79 Chinese hamster lung cells using the micronucleus assay. Cp(2)MoCl(2) produced significant genotoxic damage whereby 0.2micronuclei/1000 binucleated cells were induced per ... |
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Interaction of molybdocene dichloride with cysteine-containing peptides: coordination, regioselective hydrolysis, and intramolecular aminolysis.
Inorg. Chem. 44(4) , 1082-94, (2005) Reactions of the organometallic compound molybdocene dichloride (Cp2MoCl2, Cp = eta5-cyclopentadienyl) with the cysteine-containing peptides L-cysteinylglycine (Cys-Gly), N-acetyl-L-cysteine (AcCys), glycyl-L-cysteine (Gly-Cys), glycyl-L-cysteinylglycine (Gly... |
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In vitro cell growth inhibition by metallocene dichlorides.
Cancer Chemother. Pharmacol. 5(4) , 237-41, (1981) The in vitro growth-inhibiting potencies of titanocene dichloride (TDC), zirconocene dichloride (ZDC), hafnocene dichloride (HDC), vanadocene dichloride (VDC), and molybdocene dichloride (MDC) against Ehrlich ascites tumor (EAT) cells cultured in viro as perm... |
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P-S Bond scission by bis(cyclopentadienyl)molybdenum(IV) dichloride, Cp(2)MoCl(2)(aq): first documented example of an organometallic complex hydrolyzing thiophosphinates.
Inorg. Chem. 44(15) , 5537-41, (2005) Thiophosphinate hydrolysis involving P-S bond scission is desirable for the degradation of organophosphate neurotoxins, and we report the first case for such a hydrolytic process by an organometallic compound. The metallocene, bis(cyclopentadienyl)molybdenum(... |
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[On the biological action of transition metal complexes. 4. The antiviral activity of metallocene dichlorides of titanium and molybdenum (author's transl)].
Zentralbl. Bakteriol. Mikrobiol. Hyg. A. 250(4) , 425-30, (1981) In view of the fact that bis cyclopentadienyl metal dihalides are known to be anti-tumour drugs, we have investigated the antiviral activity of this type of coordination compounds. Bis cyclopentadienyl titanium dichloride (a) has shown significant antiviral e... |