5-羟基-2-甲基吲哚-3-羧酸乙酯
5-羟基-2-甲基吲哚-3-羧酸乙酯结构式
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常用名 | 5-羟基-2-甲基吲哚-3-羧酸乙酯 | 英文名 | Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate |
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| CAS号 | 7598-91-6 | 分子量 | 219.23700 | |
| 密度 | 1.282 g/cm3 | 沸点 | 406.7ºC at 760 mmHg | |
| 分子式 | C12H13NO3 | 熔点 | 205-208ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 199.7ºC |
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Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.
J. Med. Chem. 51 , 4351, (2008) 1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 50 of 0.9 and 0.6 microM, respectively, exhibited antitubuli... |
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Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.
J. Med. Chem. 45 , 3094, (2002) Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selectivity at that time. However, several newly synthesized compo... |
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5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.
J. Med. Chem. 52 , 3855, (2009) Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different species, including primates, underscore the implication of the ... |
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Badiger, J.; et al.
ARKIVOC , 217, (2009)
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Ferrer, S.; et al.
Tetrahedron 59 , 3445, (2003)
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