Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate

Modify Date: 2024-01-11 11:09:22

Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate Structure
Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate structure
Common Name Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
CAS Number 7598-91-6 Molecular Weight 219.23700
Density 1.282 g/cm3 Boiling Point 406.7ºC at 760 mmHg
Molecular Formula C12H13NO3 Melting Point 205-208ºC(lit.)
MSDS Chinese USA Flash Point 199.7ºC

 Use of Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate


Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor[1].

 Names

Name ethyl 5-hydroxy-2-methylindole-3-carboxylate
Synonym More Synonyms

  Biological Activity

Description Ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate is an active compound, and can be used in the synthesis of 2-phenylthiomethyl-indole derivatives, 2-phenylthiomethyl-indole derivative is a 5-lipoxygenase (5-LO) inhibitor[1].
Related Catalog

 Chemical & Physical Properties

Density 1.282 g/cm3
Boiling Point 406.7ºC at 760 mmHg
Melting Point 205-208ºC(lit.)
Molecular Formula C12H13NO3
Molecular Weight 219.23700
Flash Point 199.7ºC
Exact Mass 219.09000
PSA 62.32000
LogP 2.35860
Index of Refraction 1.5270 (estimate)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes F+
Safety Phrases 22-24/25
RIDADR NONH for all modes of transport
WGK Germany 3.0
HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles5

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1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 5...

Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

J. Med. Chem. 45 , 3094, (2002)

Previously, we reported on PD 102807 (41) as being the most selective synthetic M(4) muscarinic antagonist identified to date. Synthesized analogues of 41 showed no improvement in affinity and selecti...

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

J. Med. Chem. 52 , 3855, (2009)

Obesity is a major risk factor in the development of conditions such as hypertension, hyperglycemia, dyslipidemia, coronary artery disease, and cancer. Several pieces of evidence across different spec...

 Synonyms

MFCD00044575
ethyl 5-hydroxy-2-methyl-1H-indole-3-carboxylate
EINECS 231-507-7