二溴新戊二醇
二溴新戊二醇结构式
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常用名 | 二溴新戊二醇 | 英文名 | 2,2-Bis(bromomethyl)-1,3-propanediol |
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| CAS号 | 3296-90-0 | 分子量 | 261.940 | |
| 密度 | 2.0±0.1 g/cm3 | 沸点 | 370.9±42.0 °C at 760 mmHg | |
| 分子式 | C5H10Br2O2 | 熔点 | 112-114 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 178.1±27.9 °C | |
| 符号 |
GHS07, GHS08 |
信号词 | Warning |
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The utility of the guppy (Poecilia reticulata) and medaka (Oryzias latipes) in evaluation of chemicals for carcinogenicity.
Toxicol. Sci. 92(1) , 143-56, (2006) There has been considerable interest in the use of small fish models for detecting potential environmental carcinogens. In this study, both guppies (Poecilia reticulata) and medaka (Oryzias latipes) were exposed in the aquaria water to three known rodent carc... |
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NTP carcinogenesis studies of 2,2-bis(bromomethyl)-1,3-propanediol, nitromethane, and 1,2,3-trichloropropane (cas nos. 3296-90-0, 75-52-5, and 96-18-4) in guppies (Poecilia reticulata) and medaka (Oryzias latipes) (Waterborne Studies).
Natl. Toxicol. Program Tech. Rep. Ser. (528) , 1-190, (2005) The NTP chose to initiate studies in fish as an exploration of alternate or additional models for examining chemical toxicity and carcinogenicity. The use of small fish species in carcinogenicity testing offered potential advantages as a bioassay test system,... |
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Use of the Japanese medaka (Oryzias latipes) and guppy (Poecilia reticulata) in carcinogenesis testing under national toxicology program protocols.
Toxicol. Pathol. 31 Suppl , 88-91, (2003) A need exists for whole animal toxicity, mutagenesis, and carcinogenesis models that are alternative to the traditional rodent test models and that are economical, sensitive, and scientifically acceptable. Among small fish models, the Japanese medaka (Oryzias... |
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Carcinogenic activity of the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol in rodents, and comparison with the carcinogenicity of other NTP brominated chemicals.
Toxicol. Pathol. 25(6) , 541-8, (1997) Several brominated chemicals have been shown to be multisite-multispecies carcinogens in laboratory animals, and in this paper we report that the flame retardant, 2,2-bis(bromomethyl)-1,3-propanediol (BMP) is also a multisite carcinogen in both sexes of Fisch... |
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Absorption, distribution, metabolism, and excretion of 2,2-bis(bromomethyl)-1,3-propanediol in male fischer-344 rats.
Drug Metab. Dispos. 37(2) , 408-16, (2009) 2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant, previously shown to be a multisite carcinogen in experimental animals. Studies were performed to characterize the dispositional and metabolic fate of BMP after oral or intravenous adm... |
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In vitro glucuronidation of 2,2-bis(bromomethyl)-1,3-propanediol by microsomes and hepatocytes from rats and humans.
Drug Metab. Dispos. 38(6) , 957-62, (2010) 2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant used in unsaturated polyester resins. In a 2-year bioassay BMP was shown to be a multisite carcinogen in rats and mice. Because glucuronidation is the key metabolic transformation of B... |
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On the use of historical control data for trend test in carcinogenicity studies.
Biometrics 55(4) , 1273-6, (1999) Historical control data are often available in carcinogenicity studies and are included for testing dose effects in current studies. A new method is developed for incorporating the historical control information into a dose effect test. The method generalizes... |
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Comparison of 2,2-bis(bromomethyl)-1,3-propanediol induced genotoxicity in UROtsa cells and primary rat hepatocytes: relevance of metabolism and oxidative stress.
Toxicol. Lett. 222(3) , 273-9, (2013) 2,2-Bis(bromomethyl)-1,3-propanediol (BMP) is a brominated flame retardant used in urethane foams and polyester resins. In a two year dietary study, BMP caused neoplastic lesions at multiple sites including the urinary bladder of both rats and mice. However, ... |
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Predominant K-ras codon 12 G --> A transition in chemically induced lung neoplasms in B6C3F1 mice.
Toxicol. Pathol. 32(1) , 16-21, (2004) Based on long-term toxicity and carcinogenicity studies in B6C3F1 mice conducted by the National Toxicology Program, 2,2-Bis(bromomethyl)-1,3-propanediol (BMP) and tetranitromethane (TNM) have been identified as carcinogens. Following 2 yr of exposure to 312,... |
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Classification and toxicity mechanisms of novel flame retardants (NFRs) based on whole genome expression profiling.
Chemosphere 144 , 2150-7, (2015) Recently some novel alternative flame retardants (NFRs), which have been widely applied to meet demands for mandated flame retardation of products, have been detected in various matrices of the environment. However, knowledge on toxic effects and associated m... |