4,4'-二氨基二苯硫醚
4,4'-二氨基二苯硫醚结构式
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常用名 | 4,4'-二氨基二苯硫醚 | 英文名 | 4,4'-Thiodianiline |
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| CAS号 | 139-65-1 | 分子量 | 216.302 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 464.8±30.0 °C at 760 mmHg | |
| 分子式 | C12H12N2S | 熔点 | 105-107 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 234.9±24.6 °C | |
| 符号 |
GHS07, GHS08, GHS09 |
信号词 | Danger |
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Development of QSAR models for predicting hepatocarcinogenic toxicity of chemicals.
Eur. J. Med. Chem. 44 , 3658-64, (2009) A dataset comprising 55 chemicals with hepatocarcinogenic potency indices was collected from the Carcinogenic Potency Database with the aim of developing QSAR models enabling prediction of the above unwanted property for New Chemical Entities. The dataset was... |
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In vivo evaluation of diaminodiphenyls: anticonvulsant agents with minimal acute neurotoxicity.
Bioorg. Med. Chem. Lett. 19 , 5012-5, (2009) Several diaminodiphenyl analogs were assessed in vivo for their capacity to inhibit seizure induction and propagation in rodents. Both 3,4'- and 4,4'-diaminodiphenyl compounds prevented seizures for as long as 4h after maximal electric shock induction. 4,4'-D... |
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DNA fragmentation and DNA repair synthesis induced in rat and human thyroid cells by four rat thyroid carcinogens.
Toxicol. Appl. Pharmacol. 203(2) , 99-105, (2005) Four chemicals that are known to induce in rats thyroid follicular-cell adenomas and carcinomas were assayed for their ability to induce DNA damage and DNA repair synthesis in primary cultures of human thyroid cells. Significant dose-dependent increases in th... |
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4,4'-Thiodianiline.
IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 27 , 147-54, (1982)
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4,4'-Thiodianiline.
Rep. Carcinog. 12 , 404-5, (2011)
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4,4'-Thiodianiline.
Rep. Carcinog. 11 , III248-9, (2004)
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Synergistic enhancement of thyroid tumor induction by 2,4-diaminoanisole sulfate, N,N'-diethylthiourea and 4,4'-thiodianiline in male F344 rats.
Carcinogenesis 12(8) , 1515-8, (1991) Three thyroid carcinogens, 2,4-diaminoanisole sulfate (DAAS), N,N'-diethylthiourea (DETU) and 4,4'-thiodianiline (TDA), were simultaneously administered in the diet to male F344 rats at one-third the concentration of the reported TD50 levels (610, 200 and 46 ... |
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Carcinogenic effect of combined administration of 2,4-diaminoanisole sulfate, 4,4'-thiodianiline and N,N'-diethylthiourea in male Wistar rats.
Neoplasma 49(4) , 247-50, (2002) Male Wistar rats were divided into two groups. Rats of group 1 were fed basal powdered diet containing 610 ppm 2,4- diaminoanisole sulfate (DAAS), 46 ppm 4,4'-thiodianiline (TDA) and 200 ppm N,N'-diethylthiourea (DETU) for 52 weeks (DTD treatment). Rats of gr... |
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Toxicity of aromatic disulphides. III. In vivo haemolytic activity of aromatic disulphides.
J. Appl. Toxicol. 5(6) , 414-7, (1985) Diphenyl disulphide, 4,4'-diaminodiphenyl disulphide, 2,2'-diaminodiphenyl disulphide, 4,4'-dimethyldiphenyl disulphide and 4,4'-dinitrodiphenyl disulphide, when administered orally to rats, induced haematological and pathological changes indicative of erythr... |
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Toxicity of aromatic disulphides. II. Intraerythrocytic hydrogen peroxide formation and oxidative damage by aromatic disulphides.
J. Appl. Toxicol. 5(6) , 409-13, (1985) Diphenyl disulphide has been shown to generate hydrogen peroxide in erythrocytes in vitro. It also induces oxidative damage (reversible and irreversible haemoglobin oxidation, depletion of non-protein and protein-bound thiols) in these cells. Such changes wer... |