4-氯-L-苯基丙氨酸
4-氯-L-苯基丙氨酸结构式
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常用名 | 4-氯-L-苯基丙氨酸 | 英文名 | Fenclonine |
|---|---|---|---|---|
| CAS号 | 14173-39-8 | 分子量 | 199.634 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 339.5±32.0 °C at 760 mmHg | |
| 分子式 | C9H10ClNO2 | 熔点 | 235-238ºC | |
| MSDS | 中文版 美版 | 闪点 | 159.1±25.1 °C | |
| 符号 |
GHS06 |
信号词 | Danger |
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Disrupting monotony during social isolation stress prevents early development of anxiety and depression like traits in male rats.
BMC Neurosci. 16 , 2, (2015) Although there have been several reports on social isolation induced mood alterations, the independent contribution of monotonous environment in mediating mood alterations has been less studied. In view of the above, the present study is aimed at investigatin... |
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Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor.
Sci. Rep. 5 , 11582, (2015) The development of new drugs for the treatment of depression is strategic to achieving clinical needs of patients. This study evaluates antidepressant-like effect and neural mechanisms of four oleanolic acid derivatives i.e. acrylate (D1), methacrylate (D2), ... |
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Antidepressant-like activity of ellagic acid in unstressed and acute immobilization-induced stressed mice.
Pharmacol. Rep. 64(4) , 796-807, (2012) The aim of present study was to evaluate antidepressant-like activity of ellagic acid in Swiss young male albino mice; and to explore the possible underlying mechanisms for this activity.Mice were immobilized for 150 min once only for induction of stress. Ell... |
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Gomisin N isolated from Schisandra chinensis augments pentobarbital-induced sleep behaviors through the modification of the serotonergic and GABAergic system.
Fitoterapia 96 , 123-30, (2014) The fruits of Schisandra chinensis have been used for the treatment of insomnia in oriental countries for more than thousands of years. However, the pharmacological properties and the mechanism of sedative and hypnotic effects have not yet been studied. Gomis... |
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Dual role of serotonin in the pathogenesis of indomethacin-induced small intestinal ulceration: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors.
Pharmacol. Res. 66(3) , 226-34, (2012) Serotonin (5-HT) exerts multiple physiological functions not only in the central and peripheral nervous systems but also in the gastrointestinal tract, and these multiple functions are accounted for by a variety of 5-HT receptor subtypes. We investigated the ... |
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A possible participation of transient receptor potential vanilloid type 1 channels in the antidepressant effect of fluoxetine
Eur. J. Pharmacol. 685(1-3) , 81-90, (2012) The present study investigated the influence of transient receptor vanilloid type 1 (TRPV1) channel agonist (capsaicin) and antagonist (capsazepine) either alone or in combination with traditional antidepressant drug, fluoxetine; or a serotonin hydroxylase in... |
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Pharmacological mechanisms of antidepressant-like effect of tipepidine in the forced swimming test
Behav. Brain Res. 226(2) , 381-5, (2012) Highlights ► Tipepidine produces an antidepressant like effect in the forced swimming test. ► The effect of tipepidine may be produced via dopamine D 1 and alpha2 adrenoceptor. ► The properties of the effect may be different from those of known antidepressant... |
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A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism.
Behav. Brain Res. 233(1) , 113-9, (2012) The neurotransmitter serotonin (5-HT) is involved in the regulation of mouse intermale aggression. Previously, it was shown that intensity of mouse intermale aggression was positively associated with activity of the key enzyme of 5-HT synthesis - tryptophan h... |
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A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
J. Chromatogr. A. 1218(37) , 6302-7, (2011) Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult to reproduce. Once a column has been exposed to a modifier, ... |
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Induction of glucose intolerance by acute administration of rimonabant.
Pharmacology 89(5-6) , 339-47, (2012) Rimonabant is a cannabinoid CB1 receptor antagonist. Other CB1 antagonists have biphasic effects on blood glucose levels following acute administration. We therefore tested the effects of rimonabant on glucose tolerance following acute administration.We teste... |