肾上腺酮21-乙酯
肾上腺酮21-乙酯结构式
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常用名 | 肾上腺酮21-乙酯 | 英文名 | Pregn-4-ene-3,20-dione,21-(acetyloxy)-11-hydroxy-, (11b)- |
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| CAS号 | 1173-26-8 | 分子量 | 388.49700 | |
| 密度 | 1.2g/cm3 | 沸点 | 542.2ºC at 760 mmHg | |
| 分子式 | C23H32O5 | 熔点 | 151ºC | |
| MSDS | 中文版 美版 | 闪点 | 183.5ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Ontogeny of gastric mucosal permeability responses to luminal H+ and bile salt in the rat.
Am. J. Physiol. 250(5 Pt 1) , G617-24, (1986) Gastric mucosal responses to intraluminal instillation of acid (10, 50, and 150 mM HCl) and acidified solutions of sodium taurocholate (10 mM) were measured in rats between 5 and 60 days after birth. Net loss of H+ and gain of Na+, K+, and protein into the ga... |
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Chronic administration of corticosterone impairs LH signal transduction and steroidogenesis in rat Leydig cells.
J. Steroid Biochem. Mol. Biol. 72(3-4) , 155-62, (2000) The mechanism involved in the inhibitory actions of chronic corticosterone treatment on Leydig cell steroidogenesis was studied in adult Wistar rats. Rats were treated with corticosterone-21-acetate (2 mg/100 g body weight, i.m., twice daily) for 15 days and ... |
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Sensitivity to corticosterone-induced cleft palate is not associated with H-2.
Proc. Soc. Exp. Biol. Med. 176(1) , 14-21, (1984) The frequency of cleft palate (CP) and corticosterone levels in maternal plasma and amniotic fluid were determined in pregnant C57BL/10 (H-2b) and congenic B10.A (H-2a) mice after the ip injection of repository ACTH, corticosterone acetate, or desoxycorticost... |
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Corticosterone induces rat liver alcohol dehydrogenase mRNA but not enzyme protein or activity.
Alcohol. Clin. Exp. Res. 16(3) , 427-31, (1992) Glucocorticoids induced ADH activity and mRNA 2- to 4-fold in rat hepatoma cells (H4IIE and H4IIEC3), but were reported not to alter ADH activity in rat liver. The failure of corticosteroids to induce ADH may have been due to the short-term treatment of the r... |
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Development of gastric somatostatin-like immunoreactivity in response to corticosterone acetate and dietary changes in young rats.
Acta Endocrinol. 112(3) , 383-7, (1986) The effects of dietary changes from breast milk to solid food and corticosterone acetate administration on somatostatin-like immunoreactivity (SLI) in the gastric antrum and corpus were studied in young and adult rats. At 7 days of age, a single dose of corti... |
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Influence of corticosterone acetate on the spleen in intact and ovariectomized rats.
Endocrinol. Jpn. 39(6) , 549-54, (1992) Increasing evidence of the interaction of glucocorticoids and ovarian steroids prompted the current study. Effects of exogenously administered corticosterone acetate (3.5 mg/100 g b.w/day for one week) were examined on splenic nucleic acids, protein, lactate,... |
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Effect of corticosterone on carbamylcholine-, leucine-, or calcium-induced insulin secretion by the isolated perfused rat pancreas.
Endocrinology 114(4) , 1086-9, (1984) Using the isolated pancreas of male Sprague-Dawley rats, three different concentrations of glucose were tested in the perfusion medium: 4.0, 6.7, and 9.4 mM. The insulinotropic effects of several potent secretagogues were examined with and without a 10(-7)-M ... |
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Corticosterone impairs the mRNA expression and activity of 3beta- and 17beta-hydroxysteroid dehydrogenases in adult rat Leydig cells.
Biochem. Cell Biol. 84(5) , 745-54, (2006) Clinical and experimental studies, including our own observations, have shown the adverse effects of excess glucocorticoids on testicular steroid hormone production. The present study was designed to gain insight into the molecular mechanisms by which excess ... |
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Exogenous corticosterone acetate attenuates the hypotension induced by ganglion blockade in conscious Long Evans and Brattleboro rats.
J. Pharmacol. Exp. Ther. 243(3) , 1048-54, (1987) The effects of acute administration of corticosterone acetate (7.5 mg/kg bolus; 5 mg.kg-1h-1 infusion) on plasma corticosterone levels and blood pressure (BP) responses to hypotension induced by ganglion blockade (with pentolinium) were studied in conscious L... |
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Corticosterone 21-acetate in vivo induces acute stress in chicken thymus: cell proliferation, apoptosis and cytokine responses.
Histol. Histopathol. 19(3) , 693-9, (2004) In vivo effects of acute stress induced by corticosterone 21-acetate in male Gallus domesticus thymus are studied and the steroid actions are evaluated in terms of cell proliferation, apoptosis and cytokine response in 10- and 21-day-old chickens. Steroid tre... |