7-苄氧基-3H-吩恶嗪-3-酮
7-苄氧基-3H-吩恶嗪-3-酮结构式
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常用名 | 7-苄氧基-3H-吩恶嗪-3-酮 | 英文名 | Resorufin benzyl ether |
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| CAS号 | 87687-02-3 | 分子量 | 303.31100 | |
| 密度 | 1.26 g/cm3 | 沸点 | 479.9ºC at 760 mmHg | |
| 分子式 | C19H13NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | N/A | |
| 符号 |
GHS07 |
信号词 | Warning |
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Modulation of cytochrome P450 2A5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship.
PLoS ONE 10(1) , e0117842, (2015) Mouse cytochrome P450 (CYP) 2A5 is induced by inflammatory conditions and infectious diseases that down-regulate the expression and activity of most other CYP isoforms. Enhanced oxidative stress and nuclear factor (erythroid 2-related factor) 2 (Nrf2) transcr... |
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Inhibition of cytochrome P450 2B4 by environmentally persistent free radical-containing particulate matter.
Biochem. Pharmacol. 95 , 126-32, (2015) Combustion processes generate particulate matter (PM) that can affect human health. The presence of redox-active metals and aromatic hydrocarbons in the post-combustion regions results in the formation of air-stable, environmentally persistent free radicals (... |
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Inhibition against mosquito cytochrome P450 enzymes by rhinacanthin-A, -B, and -C elicits synergism on cypermethrin cytotoxicity in Spodoptera frugiperda cells.
J. Med. Entomol. 49(5) , 993-1000, (2012) Rhinacanthus nasutus (Acanthaceae) is a shrub reported to contain insecticidal activities. The current study was conducted to determine whether R. nasutus constituents could inhibit benzyloxyresorufin O-debenzylation (BROD) mediated by CYP6AA3 and CYP6P7. Bot... |
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An in silico transwell device for the study of drug transport and drug-drug interactions.
Pharm. Res. 24(12) , 2171-86, (2007) Validate and exemplify a discrete, componentized, in silico, transwell device (ISTD) capable of mimicking the in vitro passive transport properties of compounds through cell monolayers. Verify its use for studying drug-drug interactions.We used the synthetic ... |
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Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide.
Arch. Biochem. Biophys. 458(2) , 167-74, (2007) Based on recent directed evolution of P450 2B1, six P450 2B11 mutants at three positions were created in an N-terminal modified construct termed P450 2B11dH and characterized for enzyme catalysis using five substrates. Mutant I209A demonstrated a 3.2-fold enh... |
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Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.
Arch. Biochem. Biophys. 335(1) , 152-60, (1996) Based on recent studies of single reciprocal mutants of cytochrome P450 2B4 and the highly related P450 2B5 at positions 114, 294, 363, and 367 [G. D. Szklarz, Y. Q. He, K. M. Kedzie, J. R. Halpert, and V. L. Burnett (1996) Arch. Biochem. Biophys. 327,308-318... |
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Benzyloxyresorufin as a specific substrate for the major phenobarbital-inducible dog liver cytochrome P450 (P4502B11).
Drug Metab. Dispos. 23(12) , 1434-5, (1995)
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Tertiary butyl alcohol in drinking water induces phase I and II liver enzymes with consequent effects on thyroid hormone homeostasis in the B6C3F1 female mouse.
J. Appl. Toxicol. 30(2) , 125-32, (2010) Tertiary butyl alcohol (TBA) was administered to groups of 15 female B6C3F1 mice in drinking water at concentrations of 0, 2.0 or 20 mg TBA ml(-1), for 14 days, for assessment of gross and histological changes in the liver and thyroid, thyroid hormones (T3, T... |
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Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice.
Can. J. Physiol. Pharmacol. 71(2) , 188-90, (1993) Mouse hepatitis is a common highly infectious virus of the Coronaviridae family that commonly infects laboratory colonies of BALB/c mice. In a natural outbreak of this disease in our institution we demonstrated that mouse hepatitis virus appears to have littl... |
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Phospholipase-induced modulation of rat liver mixed-function oxidase activity.
Biochem. Soc. Trans. 27(4) , 371-4, (1999)
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