6β-羟基睾酮与甲醇的配制溶液
6β-羟基睾酮与甲醇的配制溶液结构式
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常用名 | 6β-羟基睾酮与甲醇的配制溶液 | 英文名 | 6 β hydroxy testosterone |
|---|---|---|---|---|
| CAS号 | 62-99-7 | 分子量 | 304.424 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 479.8±45.0 °C at 760 mmHg | |
| 分子式 | C19H28O3 | 熔点 | ≥205ºC | |
| MSDS | 中文版 美版 | 闪点 | 258.1±25.2 °C | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Testosterone-metabolizing capacity and characteristics of adrenal microsomes in human fetus in vitro.
J. Pediatr. Endocrinol. Metab. 23(1-2) , 143-52, (2010) We describe the metabolite spectrum of testosterone (T) in human fetal adrenal in vitro, and verify possible roles of CYP3A and 2C isoforms of human fetal adrenal in T metabolism which respond to T metabolism in liver. Isolation and identification of T and it... |
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The hepatic and intestinal metabolic activities of P450 in rats with surgery- and drug-induced renal dysfunction.
Pharm. Res. 20(10) , 1591-4, (2003) The hepatic and intestinal metabolic activities of P450 were evaluated in rats with surgery- and drug-induced renal dysfunction.Renal failure was induced by five-sixths nephrectomy (NR), bilateral ureter ligation (BUL), the intramuscular injection of glycerol... |
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The use of heat treatment to eliminate drug interactions due to grapefruit juice.
Biol. Pharm. Bull. 29(11) , 2274-8, (2006) Grapefruit juice (GJ) contains components that may increase the bioavailability of drugs; however, approaches to the removal of these components have been little investigated. It is known that furanocoumarin derivatives (FCs), such as bergamottin (BG) and 6',... |
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Autoinduction of MKC-963 [(R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine] metabolism in healthy volunteers and its retrospective evaluation using primary human hepatocytes and cDNA-expressed enzymes.
Drug Metab. Dispos. 34(6) , 950-4, (2006) MKC-963, (R)-1-(1-cyclohexylethylamino)-4-phenylphthalazine, a potent inhibitor of platelet aggregation, was synthesized and used in clinical trials in the 1990s. In the process of clinical study, it was found that urinary excretion ratios for 6beta-hydroxyco... |
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The inhibitory effect of intestinal bacterial metabolite of ginsenosides on CYP3A activity.
Biol. Pharm. Bull. 27(10) , 1555-60, (2004) The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ginse... |
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Intestinal and hepatic microsomal metabolism of testosterone and progesterone by a 3 alpha-hydroxysteroid dehydrogenase to the 3 alpha-hydroxy derivatives in the channel catfish, Ictalurus punctatus.
J. Steroid Biochem. Mol. Biol. 82(4-5) , 413-24, (2002) Intestinal or hepatic microsomes from channel catfish converted [4-14C]-testosterone to three major metabolites: 6 beta-hydroxytestosterone, androstenedione and a third metabolite. Formation of the unknown metabolite required NADPH as cofactor. When incubated... |
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The fallacy of using adrenochrome reaction for measurement of reactive oxygen species formed during cytochrome p450-mediated metabolism of xenobiotics.
J. Pharmacol. Exp. Ther. 300(2) , 417-20, (2002) The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of ... |
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Effect of classic and atypical neuroleptics on cytochrome P450 3A (CYP3A) in rat liver.
Pharmacol. Rep. 64(6) , 1411-8, (2012) Cytochrome P450 3A (CYP3A) subfamily is involved in the metabolism of xenobiotics (e.g., drugs) and endogenous substances (e.g., steroids). The aim of the present study was to investigate the influence of classic and atypical neuroleptics on the level and act... |
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The combination of chemical and antibody inhibitors for superior P450 3A inhibition in reaction phenotyping studies.
Drug Metab. Dispos. 36(12) , 2410-3, (2008) Cytochrome P450 (P450) reaction phenotyping is a key process toward accurately determining the contribution of different P450s to the metabolism of new chemical entities. The significance of P450s to drug disposition has led to the identification of selective... |
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Syntheses of stable isotope-labeled 6 beta-hydroxycortisol, 6 beta-hydroxycortisone, and 6 beta-hydroxytestosterone.
Steroids 68(7-8) , 693-703, (2003) A method is described for the preparation of two types of multi-labeled 6 beta-hydroxycortisol containing either five deuterium atoms at C-19 methyl and C-1 methylene or four 13C atoms at C-1, C-2, C-4, and C-19 in addition to the five deuterium atoms for use... |