鱼藤酮
鱼藤酮结构式
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常用名 | 鱼藤酮 | 英文名 | Rotenone |
|---|---|---|---|---|
| CAS号 | 83-79-4 | 分子量 | 394.417 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 559.8±50.0 °C at 760 mmHg | |
| 分子式 | C23H22O6 | 熔点 | 159-164 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 244.6±30.2 °C | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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High fat, high sucrose diet causes cardiac mitochondrial dysfunction due in part to oxidative post-translational modification of mitochondrial complex II.
J. Mol. Cell. Cardiol. 78 , 165-73, (2014) Diet-induced obesity leads to metabolic heart disease (MHD) characterized by increased oxidative stress that may cause oxidative post-translational modifications (OPTM) of cardiac mitochondrial proteins. The functional consequences of OPTM of cardiac mitochon... |
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Thermogenic activity of UCP1 in human white fat-derived beige adipocytes.
Mol. Endocrinol. 29(1) , 130-9, (2014) Heat-producing beige/brite (brown-in-white) adipocytes in white adipose tissue have the potential to suppress metabolic disease in mice and hold great promise for the treatment of obesity and type 2 diabetes in humans. Here, we demonstrate that human adipose-... |
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The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair.
Free Radic. Biol. Med. 76 , 278-85, (2014) DNA-dependent protein kinase catalytic subunit (DNA-PKcs) and ataxia telangiectasia mutated (ATM) are the two major kinases involved in DNA double-strand break (DSB) repair, and are required for cellular resistance to ionizing radiation. Whereas ATM is the ke... |
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The chalcone compound isosalipurposide (ISPP) exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
Toxicol. Appl. Pharmacol. 287 , 77-85, (2015) The chalcone compound isosalipurposide (ISPP) has been successfully isolated from the native Korean plant species Corylopsis coreana Uyeki (Korean winter hazel). However, the therapeutic efficacy of ISPP remains poorly understood. This study investigated whet... |
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Higher vulnerability and stress sensitivity of neuronal precursor cells carrying an alpha-synuclein gene triplication.
PLoS ONE 9(11) , e112413, (2014) Parkinson disease (PD) is a multi-factorial neurodegenerative disorder with loss of dopaminergic neurons in the substantia nigra and characteristic intracellular inclusions, called Lewy bodies. Genetic predisposition, such as point mutations and copy number v... |
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A viral peptide that targets mitochondria protects against neuronal degeneration in models of Parkinson's disease.
Nat. Commun. 5 , 5181, (2014) Mitochondrial dysfunction is a common feature of many neurodegenerative disorders, notably Parkinson's disease. Consequently, agents that protect mitochondria have strong therapeutic potential. Here, we sought to divert the natural strategy used by Borna dise... |
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U0126 protects cells against oxidative stress independent of its function as a MEK inhibitor.
ACS Chem. Neurosci. 6(1) , 130-7, (2015) U0126 is a potent and selective inhibitor of MEK1 and MEK2 kinases. It has been widely used as an inhibitor for the Ras/Raf/MEK/ERK signaling pathway with over 5000 references on the NCBI PubMed database. In particular, U0126 has been used in a number of stud... |
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HC toxin (a HDAC inhibitor) enhances IRS1-Akt signalling and metabolism in mouse myotubes.
J. Mol. Endocrinol. 55 , 197-207, (2015) Exercise enhances numerous signalling pathways and activates substrate metabolism in skeletal muscle. Small molecule compounds that activate these cellular responses have been shown to recapitulate the metabolic benefits of exercise. In this study, a histone ... |
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Inhibitors of metabolism rescue cell death in Huntington's disease models.
Proc. Natl. Acad. Sci. U. S. A. 104 , 14525-30, (2007) Huntington's disease (HD) is a fatal inherited neurodegenerative disorder. HD is caused by polyglutamine expansions in the huntingtin (htt) protein that result in neuronal loss and contribute to HD pathology. The mechanisms of neuronal loss in HD are elusive,... |
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EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-β/Smad and ROS signaling.
Cell. Mol. Life Sci. 72(10) , 2023-39, (2015) Fibrosis is an inherent response to chronic damage upon immense apoptosis or necrosis. Transforming growth factor-beta1 (TGF-β1) signaling plays a key role in the fibrotic response to chronic liver injury. To develop anti-fibrotic therapeutics, we synthesized... |