莫达非尼
一般危化品
莫达非尼结构式
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常用名 | 莫达非尼 | 英文名 | provigil |
|---|---|---|---|---|
| CAS号 | 68693-11-8 | 分子量 | 273.350 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 559.1±50.0 °C at 760 mmHg | |
| 分子式 | C15H15NO2S | 熔点 | 164-166℃ | |
| MSDS | 中文版 美版 | 闪点 | 292.0±30.1 °C | |
| 符号 |
GHS02, GHS07 |
信号词 | Danger |
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Pharmacological interventions for sleepiness and sleep disturbances caused by shift work.
Cochrane Database Syst. Rev. 8 , CD009776, (2014) Shift work results in sleep-wake disturbances, which cause sleepiness during night shifts and reduce sleep length and quality in daytime sleep after the night shift. In its serious form it is also called shift work sleep disorder. Various pharmacological prod... |
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Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
J. Natl. Cancer Inst. 106(8) , doi:10.1093/jnci/dju186, (2014) Survivors of childhood cancer frequently experience cancer-related cognitive dysfunction, commonly months to years after treatment for pediatric brain tumors, acute lymphoblastic leukemia (ALL), or tumors involving the head and neck. Risk factors for cancer-r... |
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Caffeine and modafinil promote adult neuronal cell proliferation during 48 h of total sleep deprivation in rat dentate gyrus.
Exp. Neurol. 248 , 470-81, (2013) It has been established that sleep deprivation (SD) reduces the proliferation of neuronal precursors in the adult hippocampus. It has also been reported that psychostimulant drugs modulate adult neurogenesis. We examined the modulatory role of two psychostimu... |
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A review of FDA-approved treatment options in bipolar depression.
CNS Spectr. 18 Suppl 1 , 4-20; quiz 21, (2013) OBJECTIVES/INTRODUCTION: Herein we review the evidence supporting Food and Drug Administration (FDA) approved and emerging treatments for bipolar depression.A PubMed search of all English-language articles published up to July 2013 was conducted. The search t... |
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Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Cochrane Database Syst. Rev. 12 , CD011335, (2014) Cognitive deficits are common in people who have received cranial irradiation and have a serious impact on daily functioning and quality of life. The benefit of pharmacological and non-pharmacological treatment of cognitive deficits in this population is uncl... |
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Fatigue in multiple sclerosis - a brief review.
J. Neurol. Sci. 323(1-2) , 9-15, (2012) Fatigue is the most common and debilitating symptom in multiple sclerosis (MS) and is believed to be distinctly different from fatigue seen in other chronic conditions. It can affect a patient's mood, sleep and have a detrimental effect on their quality of li... |
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Safety profile of modafinil across a range of prescribing indications, including off-label use, in a primary care setting in England: results of a modified prescription-event monitoring study.
Drug Saf. 36(4) , 237-46, (2013) Modafinil (Provigil) was marketed in the UK in 1998 to promote wakefulness in the treatment of narcolepsy. In April 2004, the licence was extended to include chronic pathological conditions; 2 years later, the prescription of modafinil was restricted to patie... |
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Cognitive effects of two nutraceuticals Ginseng and Bacopa benchmarked against modafinil: a review and comparison of effect sizes.
Br. J. Clin. Pharmacol. 75(3) , 728-37, (2013) Over recent years there has been increasing research into both pharmaceutical and nutraceutical cognition enhancers. Here we aimed to calculate the effect sizes of positive cognitive effect of the pharmaceutical modafinil in order to benchmark the effect of t... |
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Interactions between modafinil and cocaine during the induction of conditioned place preference and locomotor sensitization in mice: implications for addiction.
Behav. Brain Res. 235(2) , 105-12, (2012) Modafinil is a wake-promoting drug effective at enhancing alertness and attention with a variety of approved and off-label applications. The mechanism of modafinil is not well understood but initial studies indicated a limited abuse potential. A number of rec... |
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Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum.
PLoS ONE 7(10) , e46599, (2012) Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine dependence. Th... |