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5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮

5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮结构式
5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮结构式
品牌特惠专场
常用名 5-(6-喹喔啉亚甲基)-2,4-噻唑啉二酮 英文名 AS-605240
CAS号 648450-29-7 分子量 257.268
密度 1.6±0.1 g/cm3 沸点 N/A
分子式 C12H7N3O2S 熔点 N/A
MSDS 中文版 美版 闪点 N/A
符号 GHS07
GHS07
信号词 Warning

PI3K inhibition synergizes with glucocorticoids but antagonizes with methotrexate in T-cell acute lymphoblastic leukemia.

Oncotarget 6 , 13105-18, (2015)

The PI3K pathway is frequently hyperactivated in primary T-cell acute lymphoblastic leukemia (T-ALL) cells. Activation of the PI3K pathway has been suggested as one mechanism of glucocorticoid resistance in T-ALL, and patients harboring mutations in the PI3K ...

Short-term hypoxia enhances the migratory capability of dendritic cell through HIF-1α and PI3K/Akt pathway.

J. Cell Physiol. 229(12) , 2067-76, (2014)

Hypoxia represents an inadequate oxygen supply to tissues, which can modulate cell functions, primarily through the hypoxia-inducible transcription factor HIF-1α. Dendritic cells (DC) are professional antigen-presenting cells and their migration maybe affecte...