2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺
2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺结构式
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常用名 | 2-(5-氯-2-氟苯基)-N-4-吡啶基-4-蝶啶胺 | 英文名 | SD-208 |
|---|---|---|---|---|
| CAS号 | 627536-09-8 | 分子量 | 352.753 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 460.4±45.0 °C at 760 mmHg | |
| 分子式 | C17H10ClFN6 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 232.2±28.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Inhibition of Transforming Growth Factor-β (TGF-β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer.
J. Cell. Biochem. 116 , 1797-805, (2015) Transforming growth factor-β (TGF-β), regulates cell proliferation, angiogenesis, metastasis, and is an inducer of epithelial-mesenchymal transition (EMT). Cancer cells exhibit activated TGF-β/SMAD signaling pathway and its inhibition is an attractive strateg... |
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Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?
Invest. Ophthalmol. Vis. Sci. 51(4) , 1857-65, (2010) Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a multipotent cytokine acting through its receptors ALK5 and -1, has been postulated to be involved in this phenomenon. In light of this... |
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SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.
Cancer Res. 64 , 7954-7961 , (2004) The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas. Here we characterize the effects of a novel TGF-beta recep... |
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Progesterone inhibits endometrial cancer invasiveness by inhibiting the TGFβ pathway.
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Differential regulation of TGF-β-induced, ALK-5-mediated VEGF release by SMAD2/3 versus SMAD1/5/8 signaling in glioblastoma.
Neuro. Oncol. 17(2) , 254-65, (2015) The transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF) pathways have a major role in the pathogenesis of glioblastoma, notably immunosuppression, migration, and angiogenesis, but their interactions have remained poorly understood... |
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Overexpression of smad7 blocks primary tumor growth and lung metastasis development in osteosarcoma.
Clin. Cancer Res. 20(19) , 5097-112, (2014) Osteosarcoma is the main malignant primary bone tumor in children and adolescents for whom the prognosis remains poor, especially when metastasis is present at diagnosis. Because transforming growth factor-β (TGFβ) has been shown to promote metastasis in many... |