2,3,4,5-四氢-7-羟基-1H-苯并呋喃并[2,3-c]氮杂卓-1-酮
![2,3,4,5-四氢-7-羟基-1H-苯并呋喃并[2,3-c]氮杂卓-1-酮结构式](https://image.chemsrc.com/caspic/139/521937-07-5.png)
2,3,4,5-四氢-7-羟基-1H-苯并呋喃并[2,3-c]氮杂卓-1-酮结构式
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常用名 | 2,3,4,5-四氢-7-羟基-1H-苯并呋喃并[2,3-c]氮杂卓-1-酮 | 英文名 | CID755673 |
|---|---|---|---|---|
| CAS号 | 521937-07-5 | 分子量 | 217.221 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 531.8±38.0 °C at 760 mmHg | |
| 分子式 | C12H11NO3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 275.4±26.8 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Principles of branch dynamics governing shape characteristics of cerebellar Purkinje cell dendrites.
Development 139(18) , 3442-55, (2012) Neurons develop dendritic arbors in cell type-specific patterns. Using growing Purkinje cells in culture as a model, we performed a long-term time-lapse observation of dendrite branch dynamics to understand the rules that govern the characteristic space-filli... |
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CID755673 enhances mitogenic signaling by phorbol esters, bombesin and EGF through a protein kinase D-independent pathway.
Biochem. Biophys. Res. Commun. 391 , 63-68, (2010) Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD). In the course of experiments using CID755673, we noticed that it exerted unexpected stimulatory effects on [(3)H]thymidine incorporation and cell cycle progress... |
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Novel mechanism of cytokine-induced disruption of epithelial barriers: Janus kinase and protein kinase D-dependent downregulation of junction protein expression.
Tissue Barriers 1 , e25231, (2014) The ductal epithelium plays a key role in physiological secretion of pancreatic enzymes into the digestive system. Loss of barrier properties of the pancreatic duct may contribute to the development of pancreatitis and metastatic dissemination of pancreatic t... |
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Sphingomyelin synthases regulate protein trafficking and secretion.
PLoS ONE 6 , e23644, (2011) Sphingomyelin synthases (SMS1 and 2) represent a class of enzymes that transfer a phosphocholine moiety from phosphatidylcholine onto ceramide thus producing sphingomyelin and diacylglycerol (DAG). SMS1 localizes at the Golgi while SMS2 localizes both at the ... |
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Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex.
PLoS ONE 7 , e30459, (2012) Protein kinase D1 is downregulated in its expression in invasive ductal carcinoma of the breast and in invasive breast cancer cells, but its functions in normal breast epithelial cells is largely unknown. The epithelial phenotype is maintained by cell-cell ju... |
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PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway.
Mol. Biol. Cell 24 , 222-33, (2013) Before entering mitosis, the stacks of the Golgi cisternae are separated from each other, and inhibiting this process delays entry of mammalian cells into mitosis. Protein kinase D (PKD) is known to be involved in Golgi-to-cell surface transport by controllin... |
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Estrogen regulates histone deacetylases to prevent cardiac hypertrophy.
Mol. Biol. Cell 24 , 3805-18, (2013) The development and progression of cardiac hypertrophy often leads to heart failure and death, and important modulators of hypertrophy include the histone deacetylase proteins (HDACs). Estrogen inhibits cardiac hypertrophy and progression in animal models and... |