盐酸美加明
盐酸美加明结构式
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常用名 | 盐酸美加明 | 英文名 | UNII:4956DJR58O |
|---|---|---|---|---|
| CAS号 | 826-39-1 | 分子量 | 203.752 | |
| 密度 | N/A | 沸点 | 189.3ºC at 760 mmHg | |
| 分子式 | C11H22ClN | 熔点 | >240ºC (dec.) | |
| MSDS | 美版 | 闪点 | 58.1ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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A nicotinic receptor-mediated anti-inflammatory effect of the flavonoid rhamnetin in BV2 microglia.
Fitoterapia 98 , 11-21, (2014) The alpha7 nicotinic acetylcholine receptor (nAChR) is a potential target in neuroinflammation. Screening a plant extract library identified Solidago nemoralis as containing methyl-quercetin derivatives that are relatively selective ligands for the alpha7 nAC... |
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Profiling the role of deacylation-reacylation in the lymphatic transport of a triglyceride-mimetic prodrug.
Pharm. Res. 32(5) , 1830-44, (2015) Recent studies have demonstrated the potential for a triglyceride (TG) mimetic prodrug to promote the delivery of mycophenolic acid (MPA) to the lymphatic system. Here, the metabolic pathways that facilitate the lymphatic transport of the TG prodrug (1,3-dipa... |
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Toxicity induced by F. poae-contaminated feed and the protective effect of Montmorillonite supplementation in broilers.
Food Chem. Toxicol. 74 , 120-30, (2014) The T-2 and HT-2 toxins, the main metabolites of Fusarium poae, induce toxicity in broilers and accumulate in tissues. Consequently, during the breeding process of broilers, diets are frequently supplemented with physical adsorbents to protect birds against t... |
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An HIV-encoded antisense long noncoding RNA epigenetically regulates viral transcription.
Mol. Ther. 22(6) , 1164-75, (2014) The abundance of long noncoding RNAs (lncRNAs) and their wide range of functional roles in human cells are fast becoming realized. Importantly, lncRNAs have been identified as epigenetic modulators and consequently play a pivotal role in the regulation of gen... |
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Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
J. Neurosci. 35(14) , 5680-92, (2015) Cholinergic [acetylcholine (ACh)] axons from the basal forebrain innervate olfactory bulb glomeruli, the initial site of synaptic integration in the olfactory system. Both nicotinic acetylcholine receptors (nAChRs) and muscarinic acetylcholine receptors (mACh... |
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Effective lethal mutagenesis of influenza virus by three nucleoside analogs.
J. Virol. 89(7) , 3584-97, (2015) Lethal mutagenesis is a broad-spectrum antiviral strategy that exploits the high mutation rate and low mutational tolerance of many RNA viruses. This approach uses mutagenic drugs to increase viral mutation rates and burden viral populations with mutations th... |
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Nicotinic receptors modulate the function of presynaptic AMPA receptors on glutamatergic nerve terminals in the trigeminal caudal nucleus.
Neurochem. Int. 90 , 166-72, (2015) In this study, we demonstrate the existence on trigeminal caudal nucleus (TCN) glutamatergic terminals of α4β2 nicotinic receptors (nAChRs) capable of enhancing the terminals' spontaneous release of [(3)H]d-aspartate ([(3)H]D-Asp). In rat TCN synaptosomes, sp... |
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A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.
J. Neurophysiol. 112(2) , 446-62, (2014) Nicotinic receptors form a diverse group of ligand-gated ionotropic receptors with roles in both synaptic transmission and the control of excitability. In the bag cell neurons of Aplysia, acetylcholine activates an ionotropic receptor, which passes inward cur... |
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Intravital imaging of intestinal lacteals unveils lipid drainage through contractility.
J. Clin. Invest. 125 , 4042-52, (2015) Lacteals are lymphatic vessels located at the center of each intestinal villus and provide essential transport routes for lipids and other lipophilic molecules. However, it is unclear how absorbed molecules are transported through the lacteal. Here, we used r... |
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Effects of Menthol on Nicotine Pharmacokinetic, Pharmacology and Dependence in Mice.
PLoS ONE 10 , e0137070, (2015) Although menthol, a common flavoring additive to cigarettes, has been found to impact the addictive properties of nicotine cigarettes in smokers little is known about its pharmacological and molecular actions in the brain. Studies were undertaken to examine w... |