奈非西坦
奈非西坦结构式
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常用名 | 奈非西坦 | 英文名 | Nefiracetam |
|---|---|---|---|---|
| CAS号 | 77191-36-7 | 分子量 | 246.305 | |
| 密度 | 1.2±0.1 g/cm3 | 沸点 | 458.5±33.0 °C at 760 mmHg | |
| 分子式 | C14H18N2O2 | 熔点 | 151-155°C | |
| MSDS | 中文版 美版 | 闪点 | 231.1±25.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Investigation on urinary proteins and renal mRNA expression in canine renal papillary necrosis induced by nefiracetam.
Arch. Toxicol. 79(9) , 500-7, (2005) The occurrence of renal papillary necrosis (RPN), seen only in dogs after repeated oral administration of nefiracetam, a neurotransmission enhancer, at a relatively high dose, is because of inhibition of renal prostaglandin synthesis by the nefiracetam metabo... |
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Nefiracetam and galantamine modulation of excitatory and inhibitory synaptic transmission via stimulation of neuronal nicotinic acetylcholine receptors in rat cortical neurons.
Neuroscience 160(2) , 484-91, (2009) The cholinergic and glutamatergic systems are known to be downregulated in the brain of Alzheimer's disease patients. Galantamine and nefiracetam have been shown to potentiate the phasic activity of nicotinic acetylcholine receptors (nAChRs) in the brain. Sti... |
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Anticonvulsant properties of the novel nootropic agent nefiracetam in seizure models of mice and rats.
Epilepsia 46(6) , 811-8, (2005) Nefiracetam (NEF) is a novel pyrrolidone-type nootropic agent, and it has been reported to possess various pharmacologic effects as well as cognition-enhancing effects. The present study focused on the anticonvulsant effect of NEF and its potential for antiep... |
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Negative regulation of opioid receptor-G protein-Ca2+ channel pathway by the nootropic nefiracetam.
Ann. N. Y. Acad. Sci. 1025 , 389-97, (2004) It has recently been reported that nefiracetam, a nootropic agent, is capable of attenuating the development of morphine dependence and tolerance in mice. The mechanism of this antimorphine action is not clear. The present study was designed to address this i... |
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Nefiracetam, a novel cognition-enhancing agent. An introductory overview.
Arzneimittelforschung 44(2A) , 193-4, (1994)
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Effects of Nefiracetam, a novel pyrrolidone-type nootropic agent, on the amygdala-kindled seizures in rats.
Epilepsia 46(10) , 1561-8, (2005) Nefiracetam (NEF) is a novel pyrrolidonetype nootropic agent, and it has been reported to possess various pharmacologic effects as well as cognition-enhancing effects. The present study focused on the effects of NEF in amygdala-kindled seizures and its potent... |
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Nefiracetam and physostigmine: separate and combined effects on learning in older rabbits.
Neurobiol. Aging 25(6) , 807-16, (2004) Physostigmine and nefiracetam were tested alone and in combination in 104 rabbits with a mean age of 28 months conditioned in the 750 ms delay eyeblink classical conditioning procedure. In Experiment 1, five doses of physostigmine (0.0005-0.2 mg/kg) enhanced ... |
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Double-blind randomized treatment of poststroke depression using nefiracetam.
J. Neuropsychiatry Clin. Neurosci. 20(2) , 178-84, (2008) In preliminary trials, nefiracetam, a gamma aminobutyric compound, enhanced blood flow and improved mood following stroke. Within 3 months following stroke with major depression, 159 patients were enrolled in a double-blind trial of nefiracetam or placebo. Re... |
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Nefiracetam attenuates post-ischemic nonconvulsive seizures in rats and protects neuronal cell death induced by veratridine and glutamate.
Life Sci. 92(22) , 1055-63, (2013) Stroke patients are at a high risk of developing post-ischemic seizures and cognitive impairment. Nefiracetam (NEF), a pyrrolidone derivative, has been shown to possess both anti-epileptic and cognitive-enhancing properties. In this study the anti-seizure eff... |
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Effects of nefiracetam on the levels of brain-derived neurotrophic factor and synapsin I mRNA and protein in the hippocampus of microsphere-embolized rats.
Eur. J. Pharmacol. 507(1-3) , 49-56, (2005) Our recent study demonstrated that nefiracetam, N-(2,6-dimethylphenyl)-2-(2-oxo-1-pyrrolidinyl) acetamide, prevented impairment of the cyclic AMP (cAMP)/cAMP-responsive element binding (CREB) protein signaling pathway in sustained cerebral ischemia. The purpo... |