盐酸对碘可乐定
盐酸对碘可乐定结构式
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常用名 | 盐酸对碘可乐定 | 英文名 | p-iodoclonidine hydrochloride |
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| CAS号 | 108294-53-7 | 分子量 | 392.45100 | |
| 密度 | 2.08g/cm3 | 沸点 | 375.8ºC at 760mmHg | |
| 分子式 | C9H9Cl3IN3 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 181.1ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Imidazoline and alpha(2a)-adrenoceptor binding sites in postmenopausal women before and after estrogen replacement therapy.
Biol. Psychiatry 48(9) , 932-9, (2000) Platelet alpha(2A)-adrenoceptors (alpha(2A)AR) and imidazoline binding sites (subtype I(1)) have been proposed as peripheral markers of brain stem receptors that mediate sympathetic outflow and are reported to be elevated in major depression.In our study, p[(... |
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Pharmacological characterization of [3H]idazoxan, [3H]RX821002 and p-[125I]iodoclonidine binding to alpha 2-adrenoceptors in rat cerebral cortical membranes.
Eur. J. Pharmacol. 258(1-2) , 67-76, (1994) Binding characteristics of alpha 2-adrenoceptors in rat cerebral cortical membranes were compared using the antagonist radioligands [3H]idazoxan, [3H]2-(2-methoxy-1,4-benzodioxan-2-yl)-2-imidazoline ([3H]RX821002), and the partial agonist radioligand [125I]2-... |
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Catecholamines and angiotensinogen gene expression in kidney proximal tubular cells.
Mol. Cell Biochem. 212(1-2) , 73-9, (2000) To investigate the molecular mechanism(s) of action of catecholamines on the expression of the angiotensinogen (ANG) gene in kidney proximal tubular cells, we used opossum kidney (OK) cells with a fusion gene containing the 5'-flanking regulatory sequence of ... |
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Imidazoline receptor antisera-selected (IRAS) cDNA: cloning and characterization.
DNA Cell. Biol. 19(6) , 319-29, (2000) The imidazoline-1 receptor (IR1) is considered a novel target for drug discovery. Toward cloning an IR1, a truncated cDNA clone was isolated from a human hippocampal lambda gt11 cDNA expression library by relying on the selectivity of two antisera directed ag... |
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Membrane localization and guanine nucleotide sensitivity of medullary I1-imidazoline binding sites.
Neurochem. Int. 30(1) , 17-23, (1997) Imidazoline binding sites are labeled by [3H]clonidine (I1) or by [3H]idazoxan (I2). I2-sites are mitochondrial. The subcellular localization of I1-sites in brain is unknown. Crude membranes from bovine rostral ventrolateral medulla (RVLM) were further purifi... |
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Hypothalamic adrenergic receptor changes in the metabolic syndrome of genetically obese (ob/ob) mice.
Am. J. Physiol. Regul. Integr. Comp. Physiol. 279(2) , R505-14, (2000) The genetically, seasonally, and diet-induced obese, glucose-intolerant states in rodents, including ob/ob mice, have each been associated with elevated hypothalamic levels of norepinephrine (NE). With the use of quantitative autoradiography on brain slices o... |
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Chronic imipramine treatment downregulates IR1-imidazoline receptors in rat brainstem.
Life Sci. 61(19) , 1973-83, (1997) One subtype of imidazoline receptors (IR1) is similar to alpha 2-adrenoceptors (alpha 2 AR) based on their high affinity for clonidine and related imidazoline compounds. On the other hand, IR1 possess low affinity for norepinephrine (NE) and other catecholami... |
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Interaction of morphine but not fentanyl with cerebral alpha2-adrenoceptors in alpha2-adrenoceptor knockout mice.
J. Pharm. Pharmacol. 61(7) , 901-10, (2009) alpha(2)-Adrenergic and mu-opioid receptors belong to the rhodopsin family of G-protein coupled receptors and mediate antinociceptive effects via similar signal transduction pathways. Previous studies have revealed direct functional interactions between both ... |
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Meperidine, remifentanil and tramadol but not sufentanil interact with alpha(2)-adrenoceptors in alpha(2A)-, alpha(2B)- and alpha(2C)-adrenoceptor knock out mice brain.
Eur. J. Pharmacol. 582 , 70-77, (2008) alpha(2)-adrenoceptor agonists like clonidine or dexmedetomidine increase the sedative and analgesic actions of opioids. Furthermore opioids like meperidine show potent anti-shivering effects like alpha(2)-adrenoceptor agonists. The underlying molecular mecha... |
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Alpha 2-agonist binding sites in brain: [125I]para-iodoclonidine versus [3H]para-aminoclonidine.
Brain Res. Bull. 32 , 97, (1993) The localization of alpha 2-receptors was determined by quantitative autoradiography using [125I]para-iodoclonidine ([125I]PIC) and [3H]para-aminoclonidine ([3H]PAC). In cortical tissue, [125I]PIC and [3H]PAC were equipotent in their capacity to bind sites re... |