5-氨基-5-脱氧胸腺嘧啶脱氧核苷
5-氨基-5-脱氧胸腺嘧啶脱氧核苷结构式
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常用名 | 5-氨基-5-脱氧胸腺嘧啶脱氧核苷 | 英文名 | Thymidine,5'-amino-5'-deoxy- |
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| CAS号 | 25152-20-9 | 分子量 | 241.24 | |
| 密度 | 1.394 g/cm3 | 沸点 | N/A | |
| 分子式 | C10H15N3O4 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Measurement of carbamoylating activity of nitrosoureas and isocyanates by a novel high-pressure liquid chromatography assay.
Biochem. Pharmacol. 35(14) , 2359-65, (1986) A new assay for carbamoylating activity using reversed phase liquid chromatography (HPLC) is described which offers several advantages over existing assays. A comparison was made of the extent of carbamoylation of the amino group of 5'-amino-5'-deoxythymidine... |
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Novel acyclic amide-conjugated nucleosides and their analogues.
Nucleosides Nucleotides Nucleic Acids 28 , 103-117, (2009) An effective one-step synthesis of new amide-conjugated nucleosides and their analogues, in the presence of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM) as the condensing agent, is presented. Substrate subunits carrying carboxyl... |
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Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas and corresponding phenyl isocyanates to 5'-amino-5'-deoxythymidine: importance of carbamoylation in mouse skin carcinogenic processes.
Carcinogenesis 13(4) , 699-702, (1992) Carbamoylation reactions of N-methyl-N'-aryl-N-nitrosoureas (I-X: X = -OCH3, -CH3, -H, -Cl, and -COCH3) and of their corresponding phenyl isocyanates (II-X: X = -OCH3, -CH3, -H, -Cl and -COCH3) to the amino group of 5'-amino-5'-deoxythymidine have been kineti... |
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Template-directed addition of nucleosides to DNA by the BfiI restriction enzyme.
Nucleic Acids Res. 36 , 3969-3977, (2008) Restriction endonucleases catalyse DNA cleavage at specific sites. The BfiI endonuclease cuts DNA to give staggered ends with 1-nt 3'-extensions. We show here that BfiI can also fill in the staggered ends: while cleaving DNA, it can add a 2'-deoxynucleoside t... |
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Modulation of the metabolism and cytotoxicity of iododeoxyuridine by 5'-amino-5'-deoxythymidine.
Mol. Pharmacol. 23(3) , 709-16, (1983) In HeLa and Vero cells the antiproliferative effects of iododeoxyuridine (IdUrd) were modulated in a biphasic manner by 5'-amino-5'-deoxythymidine (5'-AdThd). Low concentrations of 5'-AdThd increased the cytotoxicity of IdUrd whereas high concentrations of 5'... |
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Effects of nucleoside analogues on the expression of herpes simplex type 1-induced proteins.
Antiviral Res. 2(5) , 267-81, (1982) Exposure of herpes simplex virus type 1 (HSV-1)-infected Vero cells to the nucleoside analogues 5-iodo-5'-amino-2',5'-dideoxyuridine (AIdUrd), 5-iodo-2'-deoxyuridine (IdUrd) or 5'-amino-2',5'-dideoxythymidine (5'-AdThd) resulted in altered expression of HSV-1... |
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Synthesis and in vitro antiviral activity of 3'-O-acyl derivatives of 5'-amino-5'-deoxythymidine: potential prodrugs for topical application.
J. Pharm. Sci. 73(11) , 1568-71, (1984) A series of 3'-O-acyl derivatives of 5'-amino-5'-deoxythymidine (5'-NH2-TdR) (IIIa-j) was synthesized by acylation of 5'-azido-5'-deoxythymidine (I). The resulting acetoxy azides were reduced by catalytic hydrogenation to give the corresponding amines. The an... |
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Preferential inhibition of 5-trifluoromethyl-2'-deoxyuridine phosphorylation by 5'-amino-5'-deoxythymidine in uninfected versus herpes simplex virus-infected cells.
Mol. Pharmacol. 24(1) , 90-6, (1983) The cytotoxic effects of 5-trifluoromethyl-2'-deoxyuridine (CF3dUrd) were effectively antagonized by 5'-amino-5'-deoxythymidine (5'-AdThd). The antiproliferative actions of CF3dUrd were reduced in a dose-dependent manner by 5'-AdThd in both HeLa and Vero cell... |
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Enzyme regulatory site-directed drugs: study of the interactions of 5'-amino-2', 5'-dideoxythymidine (5'-AdThd) and thymidine triphosphate with thymidine kinase and the relationship to the stimulation of thymidine uptake by 5'-AdThd in 647V cells.
Mol. Pharmacol. 35(1) , 98-104, (1989) 5'-Amino-2',5'-dideoxythymidine (5'-AdThd) is a nontoxic thymidine (dThd) analogue capable of antagonizing the feedback inhibition exerted by thymidine triphosphate (dTTP) on thymidine kinase (EC 2.7.1.21). In intact cells, this results in stimulation of thym... |
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In vivo modulation of iododeoxyuridine metabolism and incorporation into cellular DNA by 5'-amino-5'-deoxythymidine in normal mouse tissues and two human colon cancer xenografts.
Clin. Cancer Res. 2(6) , 981-9, (1996) This in vivo study examines the ability of 5'-amino-5'-deoxythymidine (5'-AdThd) to modulate 5-iododeoxyuridine (IdUrd) cellular metabolism in two human colon cancer xenografts (HT 29 and HCT-116), two actively proliferating normal mouse tissues (bone marrow ... |