4-硫脲嘧啶
4-硫脲嘧啶结构式
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常用名 | 4-硫脲嘧啶 | 英文名 | 4-Thiouracil |
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| CAS号 | 591-28-6 | 分子量 | 128.152 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 388.0±34.0 °C at 760 mmHg | |
| 分子式 | C4H4N2OS | 熔点 | 295 °C (dec.)(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 188.4±25.7 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Photocrosslinking of 4-thio uracil-containing RNAs supports a side-by-side arrangement of domains 5 and 6 of a group II intron.
RNA 5(2) , 318-29, (1999) Previous studies suggested that domains 5 and 6 (D5 and D6) of group II introns act together in splicing and that the two helical structures probably do not interact by helix stacking. Here, we characterized the major Mg2+ ion- and salt-dependent, long-wave U... |
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Photoelectron spectroscopic study of the negative ions of 4-thiouracil and 2,4-dithiouracil.
J. Chem. Phys. 134(7) , 074304, (2011) We report the photoelectron spectra of the negative ions of 4-thiouracil (4-TU)(-) and 2,4-dithiouracil (2,4-DTU)(-). Both of these spectra are indicative of valence anions, and they are each dominated by a single broad band with vertical detachment energies ... |
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Mechanism and dynamics of intramolecular triplet state decay of 1-propyl-4-thiouracil and its α-methyl-substituted derivatives studied in perfluoro-1,3-dimethylcyclohexane.
Photochem. Photobiol. Sci. 10(8) , 1294-302, (2011) Zinc deficiency is causing malnutrition for nearly one third of world populations. It is especially relevant in cereal-based diets in which low amounts of mineral and protein are present. In biological systems, Zn is mainly associated with protein. Cereal gra... |
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Substrate inhibition of uracil phosphoribosyltransferase by uracil can account for the uracil growth sensitivity of Leishmania donovani pyrimidine auxotrophs.
J. Biol. Chem. 288(41) , 29954-64, (2013) The pathogenic protozoan parasite Leishmania donovani is capable of both de novo pyrimidine biosynthesis and salvage of pyrimidines from the host milieu. Genetic analysis has authenticated L. donovani uracil phosphoribosyltransferase (LdUPRT), an enzyme not f... |
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Structure and tautomerism of the neutral and monoanionic forms of 4-thiouracil derivatives.
J. Am. Chem. Soc. 96(22) , 6832-9, (1974)
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Photophysical and photochemical properties of 4-thiouracil: time-resolved IR spectroscopy and DFT studies.
J. Phys. Chem. B 118(22) , 5864-72, (2014) Intensified research interests are posed with the thionucleobase 4-thiouracil (4-TU), due to its important biological function as site-specific photoprobe to detect RNA structures and nucleic acid-nucleic acid contacts. By means of time-resolved IR spectrosco... |
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TU-tagging: cell type-specific RNA isolation from intact complex tissues.
Nature Methods 6(6) , 439-41, (2009) We found that the combination of spatially restricted uracil phosphoribosyltransferase (UPRT) expression with 4-thiouracil delivery can be used to label and purify cell type-specific RNA from intact complex tissues in Drosophila melanogaster. This method is u... |
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Thiouracil cross-linking mass spectrometry: a cell-based method to identify host factors involved in viral amplification.
J. Virol. 87(15) , 8697-712, (2013) Eukaryotic RNA viruses are known to utilize host factors; however, the identity of these factors and their role in the virus life cycle remain largely undefined. Here, we report a method to identify proteins bound to the viral RNA during amplification in cell... |
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Unimolecular photochemistry of 4-thiouracils.
Photochem. Photobiol. 81(5) , 1205-11, (2005) Unimolecular phototautomeric reactions in 4-thiouracil, 1-methyl-4-thiouracil and 6-aza-4-thiouracil were studied using the matrix-isolation technique combined with infrared absorption spectroscopy. For monomers of these compounds, isolated in solid argon at ... |
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Snf1-Dependent Transcription Confers Glucose-Induced Decay upon the mRNA Product.
Mol. Cell. Biol. 36 , 628-44, (2016) In the yeast Saccharomyces cerevisiae, the switch from respiratory metabolism to fermentation causes rapid decay of transcripts encoding proteins uniquely required for aerobic metabolism. Snf1, the yeast ortholog of AMP-activated protein kinase, has been impl... |