塞来昔布
塞来昔布结构式
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常用名 | 塞来昔布 | 英文名 | Celecoxib |
|---|---|---|---|---|
| CAS号 | 169590-42-5 | 分子量 | 381.372 | |
| 密度 | 1.4±0.1 g/cm3 | 沸点 | 529.0±60.0 °C at 760 mmHg | |
| 分子式 | C17H14F3N3O2S | 熔点 | 157-159ºC | |
| MSDS | 中文版 美版 | 闪点 | 273.7±32.9 °C | |
| 符号 |
GHS08 |
信号词 | Danger |
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HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration.
Br. J. Pharmacol. 172 , 3028-42, (2015) Angiotensin II (AngII) and IL-1β are involved in cardiovascular diseases through the induction of inflammatory pathways. HuR is an adenylate- and uridylate-rich element (ARE)-binding protein involved in the mRNA stabilization of many genes. This study investi... |
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Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1.
J. Virol. 89(4) , 2268-86, (2015) Nuclear factor erythroid 2-related factor 2 (Nrf2), the cellular master regulator of the antioxidant response, dissociates from its inhibitor Keap1 when activated by stress signals and participates in the pathogenesis of viral infections and tumorigenesis. Ea... |
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Celecoxib inhibits Ewing sarcoma cell migration via actin modulation.
J. Surg. Res. 198 , 424-33, (2015) Ewing sarcoma (ES) is an aggressive childhood solid tumor in which 30% of cases are metastatic at presentation, and subsequently carry a poor prognosis. We have previously shown that treatment with celecoxib significantly reduces invasion and metastasis of ES... |
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Validation of cyclooxygenase-2 as a direct anti-inflammatory target of 4-O-methylhonokiol in zymosan-induced animal models.
Arch. Pharm. Res. 38 , 813-25, (2015) 4-O-methylhonokiol (MH) is known to inhibit inflammation by partially understood mechanisms. Here, the anti-inflammatory mechanisms of MH were examined using enzymatic, cellular, and animal assays. In enzymatic assays, MH inhibited COX-2 activity with an IC50... |
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Pharmacological actions of the slow release hydrogen sulfide donor GYY4137 on phenylephrine-induced tone in isolated bovine ciliary artery.
Mol. Med. Report. 12 , 7649-56, (2015) Hydrogen sulfide (H2S), a colorless gas characterized by its pungent odor of rotten eggs has been reported to elicit relaxation effects on basal and pre-contracted non-ocular smooth muscles of several mammalian species. In the present study, we investigated t... |
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Hepatic ischemia and reperfusion injury in the absence of myeloid cell-derived COX-2 in mice.
PLoS ONE 9(5) , e96913, (2014) Cyclooxygenase-2 (COX-2) is a mediator of hepatic ischemia and reperfusion injury (IRI). While both global COX-2 deletion and pharmacologic COX-2 inhibition ameliorate liver IRI, the clinical use of COX-2 inhibitors has been linked to increased risks of heart... |
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Prediction of renal transporter mediated drug-drug interactions for pemetrexed using physiologically based pharmacokinetic modeling.
Drug Metab. Dispos. 43(3) , 325-34, (2015) Pemetrexed, an anionic anticancer drug with a narrow therapeutic index, is eliminated mainly by active renal tubular secretion. The in vitro to in vivo extrapolation approach used in this work was developed to predict possible drug-drug interactions (DDIs) th... |
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Simultaneous quantitative determination of celecoxib and its two metabolites using liquid chromatography-tandem mass spectrometry in alternating polarity switching mode.
J. Pharm. Biomed. Anal. 107 , 32-9, (2015) A simple and rapid quantitative analytical method for the simultaneous detection of celecoxib and its two main metabolites, hydroxycelecoxib (celecoxib-OH) and celecoxib carboxylic acid (celecoxib-COOH), in rat plasma using liquid chromatography-tandem mass s... |
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Risk factors of delirium in patients undergoing total knee arthroplasty.
Arch. Gerontol. Geriatr. 60(3) , 443-7, (2015) Although postoperative delirium is a complicated disorder in elderly individuals, no study has been examined the risk factors associated with perioperative comorbidities and clinical laboratory data while specifically focusing on only total knee arthroplasty ... |
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Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells.
J. Orthop. Res. 33 , 1756-68, (2015) The cyclooxygenase 2 (COX-2) product, prostaglandin E2 (PGE2 ), acts through a family of G protein-coupled receptors designated E-prostanoid (EP) receptors that mediate intracellular signaling by multiple pathways. However, it is not known whether crosstalk b... |