N,N'-二乙酰基肼
N,N'-二乙酰基肼结构式
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常用名 | N,N'-二乙酰基肼 | 英文名 | N'-Acetylacetohydrazide |
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| CAS号 | 3148-73-0 | 分子量 | 116.118 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 349.9±11.0 °C at 760 mmHg | |
| 分子式 | C4H8N2O2 | 熔点 | 138-140 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 183.3±19.4 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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A charged aerosol detector/chemiluminescent nitrogen detector/liquid chromatography/mass spectrometry system for regular and fragment compound analysis in drug discovery.
J. Chromatogr. A. 1411 , 63-8, (2015) In this paper, we introduce a high throughput LCMS/UV/CAD/CLND system that improves upon previously reported systems by increasing both the quantitation accuracy and the range of compounds amenable to testing, in particular, low molecular weight "fragment" co... |
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Urinary metabolic profile of isoniazid in patients who develop isoniazid-related liver damage.
Hum. Toxicol. 3(6) , 485-95, (1984) The urinary metabolite profile of isoniazid has been studied in patients receiving the drug as therapy for tuberculosis and the profile in patients suffering liver damage due to isoniazid compared with that in control patients. There were no consistent differ... |
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Levels of acetyl hydrazines and rate of acetylation of isoniazid in adult tuberculosis patients.
Indian J. Physiol. Pharmacol. 29(2) , 83-8, (1985) Patients suffering from pulmonary tuberculosis were investigated for the levels of isoniazid (INH) and its metabolites viz. acetyl-INH, mono and diacetyl hydrazines and ammonia. It was observed that 50% of the patients are slow inactivators of INH and almost ... |
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Effect of isoniazid on folic acid status in Swiss mice and rats.
Indian J. Physiol. Pharmacol. 29(3) , 133-8, (1985) Effect of isoniazid (INH) and its metabolites e.g. mono and diacetyl hydrazines (MAH and DAH respectively) was studied on circulating and tissue folates in mice (a species susceptible to INH tumorigenicity) and rats (a species resistant to INH carcinogenicity... |
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Double N-H bond activation of N,N'-bis-substituted hydrazines with stable N-heterocyclic silylene.
Dalton Trans. 41(5) , 1529-33, (2012) The reaction of N-heterocyclic silylene (NHSi) L [L = CH{(C[double bond, length as m-dash]CH(2))(CMe)(2,6-iPr(2)C(6)H(3)N)(2)}Si] with benzoylhydrazine, 1,2-dicarbethoxyhydrazine, 1,2-diacetylhydrazine and 1,2-bis(tert-butoxycarbonyl)hydrazine in 1 : 1 molar ... |
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Pharmacokinetics of the toxic hydrazino metabolites formed from isoniazid in humans.
J. Pharmacol. Exp. Ther. 235(3) , 566-70, (1985) The plasma concentrations of isoniazid and its hydrazino metabolites, acetylisoniazid, acetylhydrazine and diacetylhydrazine, were measured by gas chromatography-mass spectrometry in 12 healthy subjects after the ingestion of 300 mg of isoniazid. The area und... |
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Synthesis and insecticidal activities of novel N-sulfenyl-N'-tert-butyl-N,N'-diacylhydrazines. 2. N-substituted phenoxysulfenate derivatives.
J. Agric. Food Chem. 56(13) , 5254-9, (2008) A series of novel N-substituted phenoxysulfenyl- N'- tert-butyl- N, N'-diacylhydrazines were designed and synthesized as insect growth regulators via the key intermediates N-chlorosulfenyl- N'- tert-butyl- N, N'-diacylhydrazines. Compared to the parent compou... |
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Determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine in biological fluids by high-performance liquid chromatography.
J. Chromatogr. A. 338(1) , 113-22, (1985) A high-performance liquid chromatographic assay for the determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine (plasma and urine) was developed. The m-chlorobenzoyl derivatives of isoniazid, acetylhydrazine and the internal standar... |
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Mutagenicity and carcinogenicity of mono- and diacetyl hydrazine.
Cancer Lett. 23(2) , 235-40, (1984) Two hydrazine derivatives, monoacetyl hydrazine (MAH) and diacetyl hydrazine (DAH), have been tested for mutagenic response in the Salmonella/mammalian microsome assay and micronucleus test. MAH but not DAH, increased the revertant mutants in TA100 and TA1535... |