盐酸咳美芬
盐酸咳美芬结构式
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常用名 | 盐酸咳美芬 | 英文名 | caramiphen hydrochloride |
|---|---|---|---|---|
| CAS号 | 125-85-9 | 分子量 | 325.87300 | |
| 密度 | N/A | 沸点 | 392.1ºC at 760mmHg | |
| 分子式 | C18H28ClNO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 124.8ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Isobolographic analysis of caramiphen and lidocaine on spinal anesthesia in rats.
Neurosci. Lett. 469(1) , 174-8, (2010) The aims of the study were to evaluate the spinal anesthetic effect of caramiphen and also assess spinal anesthetic interactions of caramiphen with lidocaine. Lidocaine, a common local anesthetic, was used as control. Dose-dependent responses of intrathecal c... |
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Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats.
Pharmacol. Biochem. Behav. 89(4) , 633-8, (2008) Antiparkinson agents possess excellent anticonvulsant properties against nerve agent-induced seizures by exerting both cholinergic and glutamatergic antagonisms. It is important, however, that drugs used as prophylactics not by themselves cause impairment of ... |
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Non-opioid antitussives inhibit endogenous glutamate release from rabbit hippocampal slices.
Brain Res. 564 , 341, (1991) The non-opioid antitussive drugs, dextromethorphan, caramiphen and carbetapentane, are also anticonvulsant. The effects of these antitussives on potassium-stimulated release of endogenous amino acids from rabbit hippocampal slices was tested. All 3 drugs sign... |
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Effects of caramiphen and phencyclidine alone and in combination on behavior in the rat.
Pharmacol. Biochem. Behav. 47(3) , 709-13, (1994) Because dextromethorphan (DM) has been shown to inhibit the locomotor stimulant effects of phencyclidine (PCP), this study explored further the possible interaction between drugs acting on DM and PCP receptor sites. Caramiphen, an antitussive that binds with ... |
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Non-opioid antitussives potentiate some behavioural and EEG effects of N-methyl-D-aspartate channel blockers.
Life Sci. 52(19) , 1547-57, (1993) The effects of the non-opioid oral antitussives dextromethorphan (DM) and caramiphen (CP) were tested against the behavioural and EEG effects elicited by the N-methyl-D-aspartate (NMDA) antagonists dizocilpine (MK 801) and phencyclidine (PCP) in rats and mice... |
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Discriminative stimulus properties of dextromethorphan in rats.
Biomed. Pharmacother. 49(10) , 456-64, (1995) Male Sprague-Dawley rats were trained to discriminate dextromethorphan (DM, 30 mg/kg, ip) from saline using a standard two-lever, fixed ratio 10, food reinforcement procedure. The DM-saline discrimination was acquired, and a range of doses of DM produced a do... |
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Anticonvulsant activity of caramiphen analogs.
Life Sci. 56(19) , 1571-6, (1995) Caramiphen potently blocks maximal electroshock (MES)-induced seizures in mice and rats. The anticonvulsant mechanism has been hypothesized to be due to high-affinity binding to sigma recognition sites in brain. To study the structure-activity relationship fo... |
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[Novel antidepressant-like action of drugs possessing GIRK channel blocking action in rats].
Yakugaku Zasshi 130(5) , 699-705, (2010) We have previously found that antitussive drugs inhibit G protein-coupled inwardly rectifying potassium (GIRK) channel currents in brain neurons. Potassium efflux through GIRK channels causes membrane hyperpolarization, and thus plays an important role in the... |
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[Scientific raisins from 125 years SMW (Swiss Medical Weekly). On Parpanit, a new agents which modifies extrapyramidal motor disorders. 1946].
Schweiz. Med. Wochenschr. 125(41) , 1959-61, (1995)
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Neuroprotective efficacy of caramiphen against soman and mechanisms of its action.
Br. J. Pharmacol. 164(5) , 1495-505, (2011) Caramiphen is a muscarinic antagonist with potent anticonvulsant properties. Here, we investigated the efficacy of caramiphen against behavioural seizures and neuropathology induced by the nerve agent soman, and revealed two mechanisms that may underlie the a... |