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(S)-(+)-1,2,3,4-四氢-1-萘酚

(S)-(+)-1,2,3,4-四氢-1-萘酚结构式
(S)-(+)-1,2,3,4-四氢-1-萘酚结构式
品牌特惠专场
常用名 (S)-(+)-1,2,3,4-四氢-1-萘酚 英文名 (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol
CAS号 53732-47-1 分子量 148.202
密度 1.1±0.1 g/cm3 沸点 254.8±0.0 °C at 760 mmHg
分子式 C10H12O 熔点 37-39ºC
MSDS 中文版 美版 闪点 99.9±11.0 °C
符号 GHS07
GHS07
信号词 Warning

Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17.

J. Med. Chem. 49 , 1818-27, (2006)

A set of 28 enantiomers comprising rigid and flexible secondary alcohols was synthesized by the asymmetric Corey-Bakshi-Shibata reduction. The enantiomerically pure alcohols were subjected to enzymatic glucuronidation assays employing the human UDP-glucuronos...

Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.

Bioorg. Med. Chem. Lett. 20 , 5274-6, (2010)

A comparison of the structures and kinetic properties of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) and its mutant enzymes (Leu308Val and Leu308Ala) indicates that Leu308 is a selectivity determinant for substrate binding. While the Leu308Val mutatio...