奥昔卡因
奥昔卡因结构式
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常用名 | 奥昔卡因 | 英文名 | Oxethazaine |
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| CAS号 | 126-27-2 | 分子量 | 467.643 | |
| 密度 | 1.1±0.1 g/cm3 | 沸点 | 630.4±55.0 °C at 760 mmHg | |
| 分子式 | C28H41N3O3 | 熔点 | 104-105°C | |
| MSDS | 中文版 美版 | 闪点 | 335.1±31.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Oxethazaine as the source of mephentermine and phentermine in athlete's urine
Forensic Sci. Int. 185(1-3) , e1-5, (2009) The urine specimens of numerous athletes were found to be positive for mephentermine both in-competition and out-of-competition in Taiwan. The donor of one specimen claimed she had only taken Mucaine ® (contains oxethazaine) for relieving symptomatic peptic u... |
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Confirming urinary excretion of mephentermine and phentermine following the ingestion of oxethazaine by gas chromatography-mass spectrometry analysis.
J. Anal. Toxicol. 34(2) , 73-7, (2010) Mephentermine and phentermine, substances prohibited in sports by the World Anti-Doping Agency, were found for the first time in urine specimens following the administration of a therapeutic medication, oxethazaine. In a recent sporting event, a urine specime... |
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A double-blind controlled study to compare the efficacy of an antacid plus oxethazaine with that of an antacid alone in the treatment of pain due to gastric or duodenal ulceration.
Curr. Med. Res. Opin. 10(2) , 128-34, (1986) A double-blind study was carried out in 40 patients with typical ulcer pain and suffering from gastric or duodenal ulcer to compare the pain-relieving efficacy of oxethazaine/magnesium and aluminium hydroxide mixture with that of the antacid combination alone... |
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Intrahepatic flow disturbance: possibility of a hidden cause of drug toxicity.
J. Pharmacol. Sci. 100(3) , 167-74, (2006) The liver has an intricate microvascular system that allows homogenous perfusion throughout the organ. However, the regulatory mechanisms of intrahepatic circulation are still unclear, and the effects of drugs on this system have rarely been reported. Oxethaz... |
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[Resorption of cyclosporin administered by oral route to renal transplant patients. Influence of breakfast and an antacid drug].
Therapie. 43(1) , 15-9, (1988)
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Mechanisms involved in the contraction of intrahepatic portal vein branches by clomipramine and oxethazaine in isolated perfused rat livers.
J. Pharmacol. Sci. 98(2) , 181-4, (2005) Clomipramine (CLM) and oxethazaine (OXZ) were previously reported to increase portal pressure by contracting portal vein branches (PVBs) in isolated perfused rat liver. In the present study, to characterize the contractile mechanisms, the effects of Y27632, H... |
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Ca2+ enhancement of hemolysis induced by the topical anesthetic oxethazaine in vitro.
Biol. Pharm. Bull. 21(12) , 1294-9, (1998) Oxethazaine (OXZ), a potent topical anesthetic, was found to induce red blood cell (RBC) lysis in vitro, depending upon concentrations of OXZ, RBC and Ca2+. In a 2% RBC suspension, 100 microM OXZ caused almost complete hemolysis in the presence of 1.3 mM Ca2+... |
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A preliminary report using oxethazaine--a potential new dental local anaesthetic.
Br. J. Oral Maxillofac. Surg. 28(1) , 26-8, (1990) Oxethazaine is the most potent local anaesthetic in use. It is claimed to be 2000 times more potent than lignocaine and 500 times more potent than cocaine as assessed in rabbits eyes. Currently, oxethazaine is used in an antacid preparation for the topical re... |
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[Separation of oxetacaine and its metabolites] .
Pharmazie 56(1) , 58-60, (2001) Oxetacaine (1), known as Tepilta, may be biotransformed to 2-5. After having tried to separate 1-5 by GC we succeeded in finding the HPLC method on Silicagel Si 60 with the eluent MeOH/TBME/HClO4. |
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Adverse drug reaction to oxethazine: a case report.
N. Z. Med. J. 108(1008) , 394, (1995)
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