12-(1-芘)月桂酸
12-(1-芘)月桂酸结构式
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常用名 | 12-(1-芘)月桂酸 | 英文名 | 1-Pyrenedodecanoic acid |
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| CAS号 | 69168-45-2 | 分子量 | 400.55200 | |
| 密度 | 1.129 g/cm3 | 沸点 | 594.5ºC at 760 mmHg | |
| 分子式 | C28H32O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 490.7ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Pyrene butanol--an efficient, selective and non-metabolized photosensitizing agent for human myeloid leukemia cells.
Leuk. Res. 16(5) , 453-62, (1992) Methods for ex vivo purging of neoplastic cells from harvested marrow are being developed to increase the efficacy of autologous transplantation. One approach is selective photosensitization, using sensitizing compounds and light radiation. Pyrene-containing ... |
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Evidence that photodynamic stress kills Zellweger fibroblasts by a nonapoptotic mechanism.
Biochim. Biophys. Acta 1402(1) , 61-9, (1998) Zellweger fibroblasts, which are devoid of peroxisomes and fail to synthesize plasmalogens, are very sensitive to the killing effect triggered by UV-activated 12-(1-pyrene) dodecanoic acid (P12). Although in some studied performed, it is assumed that reactive... |
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Analysis of cellular heterogeneity in the response of human leukemic cells to photosensitization induced by pyrene-containing fatty acid.
Leuk. Res. 13(12) , 1099-104, (1989) Incubation of cells with 12-(1-pyrene) dodecanoic acid (P12) followed by irradiation with ultraviolet light at 366 nm (UVA) resulted in cytotoxicity. We compared the photosensitivity to UVA irradiation of various human myelo-monocytic leukemic cell lines, the... |
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Newly identified Chinese hamster ovary cell mutants defective in peroxisome biogenesis represent two novel complementation groups in mammals.
Eur. J. Cell Biol. 73(4) , 352-9, (1997) We isolated peroxisome biogenesis mutants from Chinese hamster ovary (CHO) cells, using the 9-(1'-pyrene)nonanol/ultraviolet (P9OH/ UV) method and wild-type CHO-K1 cells that had been stably transfected with cDNA encoding Pex2p (formerly peroxisome assembly f... |
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Singlet oxygen scavenging by alpha-tocopherol and beta-carotene: kinetic studies in phospholipid membranes and ethanol solution.
Biofactors 7(1-2) , 31-40, (1998) The rate constants (ks) of 1O2 scavenging for alpha-tocopherol (alpha-Toc) and beta-carotene (beta-Car) were measured in liposome membranes, and compared with those in EtOH solution. 1O2 was site-specifically generated by photoirradiation using two photosensi... |
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Inhibitory effect of beta-carotene and astaxanthin on photosensitized oxidation of phospholipid bilayers.
J. Nutr. Sci. Vitaminol. 39(6) , 607-15, (1993) Large unilamellar liposomes comprising of egg yolk phosphatidylcholine (PC) was exposed to photoirradiation in the presence of methylene blue (water-soluble photosensitizer) or 12-(1-pyrene)dodecanoic acid (P-12, lipid-soluble photosensitizer) to estimate the... |
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Uptake of a fluorescent-labeled fatty acid by spiroplasma floricola cells.
Arch. Microbiol. 157(3) , 258-63, (1992) 12-(1-pyrene)dodecanoic fatty acid (P12) uptake by Spiroplasma floricola BNR-1 cells was characterized with regard to its kinetics, specificity, metabolism and susceptibility to protein and lipid inhibitors. The uptake process depended on temperature and pH, ... |
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Photosensitization of cultured cells and viruses by pyrene lipids.
Indian J. Biochem. Biophys. 27(6) , 359-62, (1990) Administration of pyrene-linked fatty acids and lipids to cultured cells or an enveloped (vesicular stomatitis) virus induced photosensitization which, following irradiation with a long ultra-violet light (LUV), resulted in killing of the cells and loss of th... |
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Inactivation of vesicular stomatitis virus by photosensitization following incubation with a pyrene-fatty acid.
FEBS Lett. 270(1-2) , 9-10, (1990) Vesicular stomatitis virus (VSV) was incubated with pyrene dodecanoic acid (P12), a fluorescent derivative of a medium-chain length fatty acid, and subjected to irradiation with a long wavelength ultra-violet light source at 366 nm (UVA). This inactivated the... |
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Interaction of pyrene-labeled monosialoganglioside GM1 micelles with cholera toxin.
Biochem. Biophys. Res. Commun. 195(3) , 1153-8, (1993) Monosialoganglioside GM1 labeled with 1-pyrene-dodecanoic acid was used to monitor interactions between cholera toxin and its receptor. Binding of cholera toxin to labeled ganglioside caused a decrease in pyrene fluorescence intensity at 480 nm concomitant wi... |