6-Iodoacetamidofluorescein
6-Iodoacetamidofluorescein结构式
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常用名 | 6-Iodoacetamidofluorescein | 英文名 | 6-Iodoacetamidofluorescein |
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| CAS号 | 73264-12-7 | 分子量 | 515.25400 | |
| 密度 | 1.95g/cm3 | 沸点 | 798.5ºC at 760 mmHg | |
| 分子式 | C22H14INO6 | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | 436.7ºC |
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Identification and localization of the 5-iodoacetamido-fluorescein reporter site on dog kidney Na,K-ATPase.
Prog. Clin. Biol. Res. 273 , 39-44, (1988)
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Chemical modifications of proteins as an aid to sequence analysis.
Methods Mol. Biol. 211 , 333-54, (2003)
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Clozapine causes oxidation of proteins involved in energy metabolism: a possible mechanism for antipsychotic-induced metabolic alterations.
Int. J. Neuropsychopharmacol. 11(8) , 1097-104, (2008) Although atypical antipsychotics are widely known to induce alterations in lipid and glucose metabolism, the mechanisms by which these alterations occur remain unknown. Several recent studies have shown that atypical antipsychotics induce oxidative stress and... |
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Probing the sulfhydryl groups of nuclear matrix proteins with 6-iodoacetamidofluorescein.
Cell Biol. Int. Rep. 14(5) , 409-18, (1990) Rat liver nuclear matrices were reacted with the fluorescent dye 6-iodoacetamidofluorescein and the matrix proteins were then separated by one and two-dimensional polyacrylamide gel electrophoresis. Upon transillumination with U.V. light it was possible to se... |
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A differential assay for the reduced and oxidized states of metallothionein and thionein.
Anal. Biochem. 333(1) , 19-26, (2004) In the cellular environment, the sulfur ligands in zinc/thiolate coordination sites of proteins can be oxidized with concomitant mobilization of zinc. The characterization of such "redox zinc switches" requires the determination of three species, i.e., the zi... |
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(Iodoacetamido)fluorescein labels a pair of proximal cysteines on the Ca2+-ATPase of sarcoplasmic reticulum.
Biochemistry 27(14) , 5233-40, (1988) Previous energy transfer studies [Squier, T. C., Bigelow, D. J., de Ancos, J. G., & Inesi, G. (1987) J. Biol. Chem. 262, 4748-4754] have utilized fluorescent iodoacetamide derivatives covalently bound to the Ca2+-ATPase of sarcoplasmic reticulum (SR), using l... |
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Changes in nucleosome structure and histone H3 accessibility. Iodoacetamidofluorescein labelling after treatment with phosphatidylserine vesicles.
Exp. Cell Res. 166(2) , 465-74, (1986) The accessibility of the sulfhydryl-specific dye 6-iodoacetamidofluorescein (IAF) to H3 histone has been studied in isolated rat liver nuclei and mononucleosomal core particles after treatment with phosphatidylserine (PS) multilamellar vesicles (MLV). In isol... |
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6-Iodoacetamidofluorescein labelling to assess the state of sulphhydril groups after thermal stabilization of isolated nuclei.
Histochem. J. 26(2) , 179-88, (1994) Isolated nuclei and nuclear matrices, prepared from mouse erythroleukaemia cells, were reacted with the sulphhydryl-specific dye 6-iodoacetamidofluorescein. To determine whether in vitro formation of disulphide bonds might play a role in the nuclear matrix st... |
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Fluorescent labeling of cysteine 39 on Escherichia coli primase places the dye near an active site.
Bioconjug. Chem. 6(6) , 673-82, (1995) Cysteine 39 of Escherichia coli primase is the most chemically reactive cysteine. Its high chemical reactivity is likely due to its proximity to primase's zinc, which is probably ligated to the adjacent residues 40-62. The zinc may stabilize the deprotonated ... |
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Clozapine treatment causes oxidation of proteins involved in energy metabolism in lymphoblastoid cells: a possible mechanism for antipsychotic-induced metabolic alterations.
J. Psychiatr. Pract. 16(5) , 325-33, (2010) There is increasing concern about the serious metabolic side effects and neurotoxicity caused by atypical (second-generation) antipsychotics. In a previous study by our group (Walss-Bass et al. Int J Neuropsychopharmacol 2008;11:1097-104), using a novel prote... |