3-氰基伞形酮
3-氰基伞形酮结构式
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常用名 | 3-氰基伞形酮 | 英文名 | 7-HYDROXY-2-OXO-2H-CHROMENE-3-CARBONITRILE |
|---|---|---|---|---|
| CAS号 | 19088-73-4 | 分子量 | 187.15200 | |
| 密度 | 1.5 g/cm3 | 沸点 | 436.6ºC at 760 mmHg | |
| 分子式 | C10H5NO3 | 熔点 | ≥250ºC(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 217.8ºC | |
| 符号 |
GHS07 |
信号词 | Warning |
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Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa.
Xenobiotica 42 , 989-1000, (2012) 1. Frutinone is an active ingredient extracted from the lipophilic fraction of the Polygala Fruticosa demonstrating various antibacterial and fungal properties. The aim of this study was to characterize its metabolism in an effort to understand metabolism bas... |
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A continuous fluorometric assay for cytochrome P-450-dependent mixed function oxidases using 3-cyano-7-ethoxycoumarin.
Anal. Biochem. 172 , 304, (1988) A direct fluorometric procedure for the continuous determination of cytochrome P-450-dependent mixed function oxidases, using 3-cyano-7-ethoxycoumarin substrate, is described. The reaction product, 3-cyano-7-hydroxycoumarin, is fluorescent at neutral pH value... |
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Assessment of cytochrome P450 fluorometric substrates with rainbow trout and killifish exposed to dexamethasone, pregnenolone-16alpha-carbonitrile, rifampicin, and beta-naphthoflavone.
Aquat. Toxicol. 97 , 324-333, (2010) Cytochrome P450s (CYPs) are important xenobiotic metabolizing proteins. While their functions are well understood in mammals, CYP function in non-mammalian vertebrate systems is much less defined, with function often inferred from mammalian data, assuming sim... |
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Differences in cytochrome P450 enzyme activities between fish and crustacea: relationship with the bioaccumulation patterns of polychlorobiphenyls (PCBs).
Aquat. Toxicol. 108 , 11-17, (2012) Variations in cytochrome P450 enzyme (CYPs) distribution and function between animal groups could result in differential metabolism and elimination kinetics for certain contaminants. Although a number of studies have suggested that differences in polychlorobi... |
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TRAM-34, a putatively selective blocker of intermediate-conductance, calcium-activated potassium channels, inhibits cytochrome P450 activity.
PLoS ONE 8 , e63028, (2013) TRAM-34, a clotrimazole analog characterized as a potent and selective inhibitor of intermediate-conductance, calcium-activated K(+) (IKCa) channels, has been used extensively in vitro and in vivo to study the biological roles of these channels. The major adv... |
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The molecular basis for the broad substrate specificity of human sulfotransferase 1A1.
PLoS ONE 6(11) , e26794, (2011) Cytosolic sulfotransferases (SULTs) are mammalian enzymes that detoxify a wide variety of chemicals through the addition of a sulfate group. Despite extensive research, the molecular basis for the broad specificity of SULTs is still not understood. Here, stru... |