环噻嗪
环噻嗪结构式
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常用名 | 环噻嗪 | 英文名 | Cyclothiazide |
|---|---|---|---|---|
| CAS号 | 2259-96-3 | 分子量 | 389.878 | |
| 密度 | 1.6±0.1 g/cm3 | 沸点 | 627.3±65.0 °C at 760 mmHg | |
| 分子式 | C14H16ClN3O4S2 | 熔点 | 234ºC | |
| MSDS | 中文版 美版 | 闪点 | 333.2±34.3 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Nicotinic receptors modulate the function of presynaptic AMPA receptors on glutamatergic nerve terminals in the trigeminal caudal nucleus.
Neurochem. Int. 90 , 166-72, (2015) In this study, we demonstrate the existence on trigeminal caudal nucleus (TCN) glutamatergic terminals of α4β2 nicotinic receptors (nAChRs) capable of enhancing the terminals' spontaneous release of [(3)H]d-aspartate ([(3)H]D-Asp). In rat TCN synaptosomes, sp... |
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AMPA receptor desensitization is the determinant of AMPA receptor mediated excitotoxicity in purified retinal ganglion cells.
Exp. Eye Res. 132 , 136-50, (2015) The ionotropic glutamate receptors (iGLuR) have been hypothesized to play a role in neuronal pathogenesis by mediating excitotoxic death. Previous studies on iGluR in the retina have focused on two broad classes of receptors: NMDA and non-NMDA receptors inclu... |
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Molecular mechanisms contributing to TARP regulation of channel conductance and polyamine block of calcium-permeable AMPA receptors.
J. Neurosci. 34(35) , 11673-83, (2014) Many properties of fast synaptic transmission in the brain are influenced by transmembrane AMPAR regulatory proteins (TARPs) that modulate the pharmacology and gating of AMPA-type glutamate receptors (AMPARs). Although much is known about TARP influence on AM... |
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Adenosine A3 receptor activation is neuroprotective against retinal neurodegeneration.
Exp. Eye Res. 140 , 65-74, (2015) Death of retinal neural cells, namely retinal ganglion cells (RGCs), is a characteristic of several retinal neurodegenerative diseases. Although the role of adenosine A3 receptor (A3R) in neuroprotection is controversial, A3R activation has been reported to a... |
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Reconstitution of homomeric GluA2(flop) receptors in supported lipid membranes: functional and structural properties.
J. Biol. Chem. 288(12) , 8647-57, (2013) AMPA receptors (AMPARs) are glutamate-gated ion channels ubiquitous in the vertebrate central nervous system, where they mediate fast excitatory neurotransmission and act as molecular determinants of memory formation and learning. Together with detailed analy... |
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Pharmacological analysis of the activation and receptor properties of the tonic GABA(C)R current in retinal bipolar cell terminals.
PLoS ONE 6(9) , e24892, (2011) GABAergic inhibition in the central nervous system (CNS) can occur via rapid, transient postsynaptic currents and via a tonic increase in membrane conductance, mediated by synaptic and extrasynaptic GABA(A) receptors (GABA(A)Rs) respectively. Retinal bipolar ... |
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Hippocampal AMPA autoreceptors positively coupled to NMDA autoreceptors traffic in a constitutive manner and undergo adaptative changes following enriched environment training.
Neuropharmacology 61(8) , 1282-90, (2011) α-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) autoreceptors exist on glutamate hippocampal terminals. Aimed at investigating whether these autoreceptors traffic constitutively, (S)AMPA-evoked [(3)H]D-ASP release from synaptosomes enriched with pept... |
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Excitatory actions of ventral root stimulation during network activity generated by the disinhibited neonatal mouse spinal cord.
J. Neurophysiol. 101(6) , 2995-3011, (2009) To further understand the excitatory effects of motoneurons on spinal network function, we investigated the entrainment of disinhibited rhythms by ventral root (VR) stimulation in the neonatal mouse spinal cord. A brief train of stimuli applied to a VR trigge... |
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A continuous high frequency stimulation of the subthalamic nucleus determines a suppression of excitatory synaptic transmission in nigral dopaminergic neurons recorded in vitro.
Exp. Neurol. 233(1) , 292-302, (2012) High frequency stimulation of the subthalamic nucleus (HFS-STN) has been successfully introduced to treat symptoms of advanced Parkinson's disease (PD) (rigidity, tremor and akinesia). In spite of its extensive clinical practice, little is known at cellular l... |
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Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats.
Seizure 20(4) , 312-9, (2011) We have previously reported that cyclothiazide (CTZ) evokes epileptiform activities in hippocampal neurons and induces seizure behavior. Here we further studied in vivo the sensitivity of the hippocampal CA1 neurons in response to CTZ in epileptogenesis in co... |