1-[2-[(二苯基亚甲基)亚氨基]氧基]乙基]-1,2,5,6-四氢 3-吡啶羧酸盐酸盐
![1-[2-[(二苯基亚甲基)亚氨基]氧基]乙基]-1,2,5,6-四氢 3-吡啶羧酸盐酸盐结构式](https://image.chemsrc.com/caspic/320/145645-62-1.png)
1-[2-[(二苯基亚甲基)亚氨基]氧基]乙基]-1,2,5,6-四氢 3-吡啶羧酸盐酸盐结构式
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常用名 | 1-[2-[(二苯基亚甲基)亚氨基]氧基]乙基]-1,2,5,6-四氢 3-吡啶羧酸盐酸盐 | 英文名 | NNC 711 |
|---|---|---|---|---|
| CAS号 | 145645-62-1 | 分子量 | 386.87200 | |
| 密度 | N/A | 沸点 | 541.2ºC at 760 mmHg | |
| 分子式 | C21H23ClN2O3 | 熔点 | 204 - 206 °C | |
| MSDS | 中文版 美版 | 闪点 | 281.1ºC |
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Intracellular Na+ concentration influences short-term plasticity of glutamate transporter-mediated currents in neocortical astrocytes.
Glia 60(4) , 605-14, (2012) Fast synaptic transmission requires a rapid clearance of the released neurotransmitter from the extracellular space. Glial glutamate transporters (excitatory amino acid transporters, EAATs) strongly contribute to glutamate removal. In this work, we investigat... |
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Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist.
Alcohol. Clin. Exp. Res. 33(1) , 108-20, (2009) The gamma-aminobutyric acid (GABA) system is implicated in the neurobiological actions of ethanol, and pharmacological agents that increase the activity of this system have been proposed as potential treatments for alcohol use disorders. As ethanol has its ow... |
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GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms.
Neuropharmacology 53(8) , 975-81, (2007) Mechanisms through which the reported antinociceptive activity of GABA re-uptake inhibitors is mediated (and where on the sensory neuraxis) have not been defined. Here, microdialysis in the anaesthetised rat was used to examine the effect of selective GABA tr... |
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Effects of gabapentin and pregabalin on K+-evoked 3H-GABA and 3H-glutamate release from human neocortical synaptosomes.
Naunyn Schmiedebergs Arch. Pharmacol. 379(4) , 361-9, (2009) One site of action of the anticonvulsant, analgesic, and anxiolytic drugs gabapentin and pregabalin is the alpha(2)delta-subunit of voltage-sensitive Ca(2+) channels (VSCC). We therefore analyzed the effects of gabapentin and pregabalin on K(+)-evoked release... |
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Using short columns to speed up LC-MS quantification in MS binding assays.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(17-18) , 1356-64, (2010) The present study describes the use of short columns to speed up LC-MS quantification in MS binding assays. The concept of MS binding assays follows closely the principle of traditional radioligand binding but uses MS for the quantification of bound marker th... |
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Effects of antiepileptic drugs on GABA release from rat and human neocortical synaptosomes.
Naunyn Schmiedebergs Arch. Pharmacol. 384(1) , 47-57, (2011) In epilepsy, allegedly, a neurotransmitter imbalance between the inhibitory GABA and the excitatory glutamate prevails. Therefore, some antiepileptic drugs (AEDs) are thought to increase GABA release. Because little is known about corresponding presynaptic ef... |
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Expanding the scope of MS binding assays to low-affinity markers as exemplified for mGAT1.
Anal. Bioanal. Chem 391(1) , 309-16, (2008) Following a recently developed concept of MS binding assays based on the quantification of a native marker by LC-MS a procedure to study binding of a low-affinity marker in kinetic, saturation, and competition experiments was established. Separation of bound ... |
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GABA uptake by purified avian Müller glia cells in culture.
Neurotox. Res. 12(2) , 145-53, (2007) GABA is the main inhibitory aminoacid transmitter present in neurons and glial cells. Its uptake is carried out by specific high-affinity Na(+)/Cl (-) dependent transporters (GATs). It has been reported in the past that, in the avian retina, [(3)H]GABA appear... |
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GABA transport modulates the ethanol sensitivity of tonic inhibition in the rat dentate gyrus.
Alcohol 45(6) , 577-83, (2011) In recent years, the effect of ethanol on tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has become a topic of intensive investigation and some controversy. The high ethanol sensitivity of extrasynaptic GABA(A) receptors containing t... |
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Hypoalgesia in mice lacking GABA transporter subtype 1.
J. Neurosci. Res. 86(2) , 465-70, (2008) gamma-Aminobutyric acid (GABA) transporters play a key role in the regulation of GABA neurotransmission. We reported previously that overexpression of the GABA transporter subtype 1 (GAT1), the major form of the GABA transporter in the CNS, led to hyperalgesi... |