NNC 711
NNC 711 structure
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Common Name | NNC 711 | ||
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| CAS Number | 145645-62-1 | Molecular Weight | 386.87200 | |
| Density | N/A | Boiling Point | 541.2ºC at 760 mmHg | |
| Molecular Formula | C21H23ClN2O3 | Melting Point | 204 - 206 °C | |
| MSDS | Chinese USA | Flash Point | 281.1ºC | |
Use of NNC 711NNC-711 (hydrochloride) is a potent and selective inhibitor of GAT-1 ( GABA transporter 1) with an IC50 of 40 nM for hGAT-1. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity[1][2][3]. |
| Name | 1-[2-(benzhydrylideneamino)oxyethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid,hydrochloride |
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| Synonym | More Synonyms |
| Description | NNC-711 (hydrochloride) is a potent and selective inhibitor of GAT-1 ( GABA transporter 1) with an IC50 of 40 nM for hGAT-1. NNC-711 has anticonvulsant and analgesic effect in vivo and exhibits cognition-enhancing activity[1][2][3]. |
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| Related Catalog | |
| References |
| Boiling Point | 541.2ºC at 760 mmHg |
|---|---|
| Melting Point | 204 - 206 °C |
| Molecular Formula | C21H23ClN2O3 |
| Molecular Weight | 386.87200 |
| Flash Point | 281.1ºC |
| Exact Mass | 386.14000 |
| PSA | 62.13000 |
| LogP | 3.91220 |
| Vapour Pressure | 1.52E-12mmHg at 25°C |
| InChIKey | YZYRTEYMUTWJPL-UHFFFAOYSA-N |
| SMILES | Cl.O=C(O)C1=CCCN(CCON=C(c2ccccc2)c2ccccc2)C1 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
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~%
NNC 711 CAS#:145645-62-1 |
| Literature: Novo Nordisk A/S Patent: US5039685 A1, 1991 ; |
| Precursor 1 | |
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| DownStream 0 | |
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Intracellular Na+ concentration influences short-term plasticity of glutamate transporter-mediated currents in neocortical astrocytes.
Glia 60(4) , 605-14, (2012) Fast synaptic transmission requires a rapid clearance of the released neurotransmitter from the extracellular space. Glial glutamate transporters (excitatory amino acid transporters, EAATs) strongly c... |
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Attenuation of the stimulant response to ethanol is associated with enhanced ataxia for a GABA, but not a GABA, receptor agonist.
Alcohol. Clin. Exp. Res. 33(1) , 108-20, (2009) The gamma-aminobutyric acid (GABA) system is implicated in the neurobiological actions of ethanol, and pharmacological agents that increase the activity of this system have been proposed as potential ... |
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GABA transporter type 1 (GAT-1) uptake inhibition reduces stimulated aspartate and glutamate release in the dorsal spinal cord in vivo via different GABAergic mechanisms.
Neuropharmacology 53(8) , 975-81, (2007) Mechanisms through which the reported antinociceptive activity of GABA re-uptake inhibitors is mediated (and where on the sensory neuraxis) have not been defined. Here, microdialysis in the anaestheti... |
| NO-711 hydrochloride |
| NO 711 |
| Nnc-711 |
| Oxyntomodulin |