盐酸咪唑克生
盐酸咪唑克生结构式
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常用名 | 盐酸咪唑克生 | 英文名 | Idazoxan Hydrochloride |
|---|---|---|---|---|
| CAS号 | 79944-56-2 | 分子量 | 240.68600 | |
| 密度 | N/A | 沸点 | 397ºC at 760 mmHg | |
| 分子式 | C11H13ClN2O2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 193.9ºC | |
| 符号 |
GHS06 |
信号词 | Danger |
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The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling.
J. Neurosci. 34(22) , 7645-56, (2014) Metabotropic transmission typically occurs through the spillover activation of extrasynaptic receptors. This study examined the mechanisms underlying somatodendritic dopamine and noradrenaline transmission and found that the extent of spillover and pooling va... |
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Mirabegron relaxes urethral smooth muscle by a dual mechanism involving β3 -adrenoceptor activation and α1 -adrenoceptor blockade.
Br. J. Pharmacol. 173 , 415-28, (2016) This article is commented on by Michel, M. C., pp. 429-430 of this issue. To view this commentary visit http://dx.doi.org/10.1111/bph.13379.Mirabegron is the first β3 -adrenoceptor agonist approved for treatment of overactive bladder syndrome. This study aime... |
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Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors
Brain Res. Bull. 86(5-6) , 412-21, (2011) Highlights ► DBV's anti-nociceptive effect involves suppression of spinal astrocyte activation. ► DBV-induced astrocyte inhibition is mediated by spinal alpha-2A and alpha-2C adrenoceptors. ► Astrocyte modulation by DBV is potentiated by i.t. administration o... |
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Discriminative stimulus effects of the novel imidazoline I₂ receptor ligand CR4056 in rats.
Sci. Rep. 4 , 6605, (2014) This study examined whether a novel imidazoline I₂ receptor ligand CR4056 could serve as a discriminative stimulus and whether it shares similar discriminative stimulus effects with other reported I₂ receptor ligands. Eight male Sprague-Dawley rats were train... |
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Involvement of α₂-adrenoceptors, imidazoline, and endothelin-A receptors in the effect of agmatine on morphine and oxycodone-induced hypothermia in mice.
Fundam. Clin. Pharmacol. 27(5) , 498-509, (2013) Potentiation of opioid analgesia by endothelin-A (ET(A)) receptor antagonist, BMS182874, and imidazoline receptor/α₂-adrenoceptor agonists such as clonidine and agmatine are well known. It is also known that agmatine blocks morphine hyperthermia in rats. Howe... |
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Effect of tapentadol on neurons in the locus coeruleus.
Neuropharmacology 72 , 250-8, (2013) Tapentadol is a novel centrally acting drug that combines mu-opioid receptor (MOR) agonism and noradrenaline reuptake inhibition (NRI), producing analgesic effects in various painful conditions. We investigated the acute effects of tapentadol in the locus coe... |
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Investigation of the vasorelaxant effects of moxonidine and its relaxation mechanism on the human radial artery when used as a coronary bypass graft.
Interact. Cardiovasc. Thorac. Surg. 21 , 342-5, (2015) In both low- and high-risk patients undergoing coronary artery bypass grafting, the internal mammary artery is the first choice of arterial graft, and the second choice is the radial artery (RA). Unfortunately, RA spasms are a significant problem for a surgic... |
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Lateral septal area α1- and α2-adrenoceptors differently modulate baroreflex activity in unanaesthetized rats.
Exp. Physiol. 97(9) , 1018-29, (2012) The lateral septal area (LSA) is a limbic structure involved in autonomic, neuroendocrine and behavioural responses. An inhibitory influence of the LSA on baroreflex activity has been reported; however, the local neurotransmitter involved in this modulation i... |
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The α1-, but not α2-, adrenoceptor in the nucleus accumbens plays an inhibitory role upon the accumbal noradrenaline and dopamine efflux of freely moving rats
Eur. J. Pharmacol. 688(1-3) , 35-41, (2012) In vivo microdialysis was used to analyse the role of the α1- and α2-adrenoceptor subtypes in the regulation of noradrenaline and dopamine efflux in the nucleus accumbens of freely moving rats. Intra-accumbal infusion of α1-adrenoceptor agonist methoxamine (2... |
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Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear.
Br. J. Pharmacol. 167(1) , 207-21, (2012) The bed nucleus of the stria terminalis (BNST) is a limbic structure that is involved in the expression of conditioned contextual fear. Among the numerous neural inputs to the BNST, noradrenergic synaptic terminals are prominent and some evidence suggests an ... |