Tyrphostin B42 (AG-490)
Tyrphostin B42 (AG-490)结构式
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常用名 | Tyrphostin B42 (AG-490) | 英文名 | Tyrphostin B42 (AG-490) |
|---|---|---|---|---|
| CAS号 | 133550-30-8 | 分子量 | 294.305 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 615.2±55.0 °C at 760 mmHg | |
| 分子式 | C17H14N2O3 | 熔点 | 215°C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 325.9±31.5 °C | |
| 符号 |
GHS06, GHS09 |
信号词 | Danger |
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Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices.
Brain Res. 816 , 587, (1999) We have investigated the effects of protein tyrosine kinases (PTKs) inhibitors on high-threshold voltage activating (HVA) calcium currents in CA1 pyramidal neurones, whole-cell patch-clamp recorded from rat hippocampal slices. Genistein (100 microM) and tyrph... |
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Constitutive STAT3-activation in Sezary syndrome: tyrphostin AG490 inhibits STAT3-activation, interleukin-2 receptor expression and growth of leukemic Sezary cells.
Leukemia 15 , 787-793, (2001) Interleukin-2 (IL-2) is a growth factor which upon binding to high-affinity receptors (IL-2Ralphabetagamma) triggers mitogenesis in T cells. IL-2Ralpha expression is restricted to T cells which have recently encountered antigen, and in healthy individuals the... |
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Granulocyte-macrophage colony-stimulating factor-activated signaling pathways in human neutrophils. Involvement of Jak2 in the stimulation of phosphatidylinositol 3-kinase.
J. Biol. Chem. 274 , 5333, (1999) Granulocyte-macrophage colony-stimulating factor (GM-CSF) regulates many of the biological activities of human neutrophils. The signaling pathways via which these effects are mediated are not fully understood. We have shown previously that GM-CSF treatment of... |
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Fyn and JAK2 mediate Ras activation by reactive oxygen species.
J. Biol. Chem. 274 , 21003-21010, (1999) Reactive oxygen species (ROS) activate Ras and the extracellular signal-regulated kinase (ERK) cascade. Because JAK2 is a critical mediator for Ras/Raf/ERK activation by several hormones, we examined the role of JAK2 in ROS signal events. H(2)O(2) stimulated ... |
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Human apolipoprotein A-I induces cyclooxygenase-2 expression and prostaglandin I-2 release in endothelial cells through ATP-binding cassette transporter A1.
Am. J. Physiol. Cell Physiol. 301(3) , C739-48, (2011) High-density lipoprotein (HDL) can induce cyclooxygenase-2 (COX-2) expression and prostacyclin I-2 (PGI-2) release in endothelial cells to exert multiple antiatherogenic functions. This effect has been attributed mainly to the role of sphingosine-1-phosphate ... |
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Soluble factor effects on glial cell reactivity at the surface of gel-coated microwires.
J. Neurosci. Methods 190(2) , 180-7, (2010) A basal lamina gel preparation was incorporated into a modified neuroinflammation cell culture model to test the system as a characterization tool for surface-modified microwires. The extent of gliosis at the surface of gel-coated microwires was quantified in... |