内皮素-1,三氟乙酸盐
内皮素-1,三氟乙酸盐结构式
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常用名 | 内皮素-1,三氟乙酸盐 | 英文名 | Endothelin-1 (human, bovine, dog, mouse, porcine, rat) acetate salt |
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| CAS号 | 117399-94-7 | 分子量 | 2491.902 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 2467.3±65.0 °C at 760 mmHg | |
| 分子式 | C109H159N25O32S5 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 1446.0±34.3 °C |
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ADP-ribosylation factor 6 regulates endothelin-1-induced lipolysis in adipocytes.
Biochem. Pharmacol. 90(4) , 406-13, (2014) Endothelin-1 (ET-1) induces lipolysis in adipocytes, where ET-1 chronic exposure results in insulin resistance (IR) through suppression of glucose transporter (GLUT)4 translocation to the plasma membrane and consequently glucose uptake. ARF6 small GTPase, whi... |
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HJP272, a novel endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury in hamsters.
Lung 192(5) , 803-10, (2014) Previous studies from this laboratory indicate that endothelin-1 (ET-1), a potent vasoconstrictor, may play an important role in lipopolysaccharide (LPS)-induced release of neutrophils from the pulmonary microvasculature. To further test this concept, Syrian ... |
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Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase.
Biochem. Pharmacol. 94(2) , 91-100, (2015) Important structural differences imply that human and mouse mast cell chymases may differ with respect to their enzymatic properties. We compared in this study the catalytic efficiencies of recombinant human chymase (rCMA1) and its functional murine homologue... |
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Endothelial cells enhance the migration of bovine meniscus cells.
Arthritis Rheumatology 67(1) , 182-92, (2014) To study the interactions between vascular endothelial cells and meniscal fibrochondrocytes from the inner avascular and outer vascular regions of the meniscus and to identify angiogenic factors that enhance cell migration and integrative repair.Bovine menisc... |
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NOS1-dependent negative feedback regulation of the epithelial sodium channel in the collecting duct.
Am. J. Physiol. Renal Physiol. 308(3) , F244-51, (2015) With an increase in urine flow there is a significant increase in shear stress against the renal epithelium including the inner medullary collecting duct, resulting in an increase in nitric oxide (NO) production. The mechanisms of the shear stress-mediated in... |
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Endothelin-1 protects human melanocytes from UV-induced DNA damage by activating JNK and p38 signalling pathways.
Exp. Dermatol. 24(4) , 269-74, (2015) Endothelin-1 is a paracrine factor with mitogenic, melanogenic and survival effects on cultured human melanocytes. We report that endothelin-1 signalling reduced the generation and enhanced the repair of ultraviolet radiation (UV)-induced DNA photoproducts, a... |
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miR-185 plays an anti-hypertrophic role in the heart via multiple targets in the calcium-signaling pathways.
PLoS ONE 10(3) , e0122509, (2015) MicroRNA (miRNA) is an endogenous non-coding RNA species that either inhibits RNA translation or promotes degradation of target mRNAs. miRNAs often regulate cellular signaling by targeting multiple genes within the pathways. In the present study, using Gene S... |
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Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1-induced pruritus.
J. Clin. Invest. 124(6) , 2683-95, (2014) In humans, pruritus (itch) is a common but poorly understood symptom in numerous skin and systemic diseases. Endothelin 1 (ET-1) evokes histamine-independent pruritus in mammals through activation of its cognate G protein-coupled receptor endothelin A recepto... |
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Endothelin-1 exacerbates development of hypertension and atherosclerosis in modest insulin resistant syndrome.
Biochem. Biophys. Res. Commun. 460 , 497-503, (2015) Endothelin-1 (ET-1) is known as potent vasoconstrictor, by virtue of its mitogenic effects, and may deteriorate the process of hypertension and atherosclerosis by aggravating hyperplasia and migration in VSMCs. Our previous study demonstrated that insulin inf... |
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Cardioprotective effects of early and late aerobic exercise training in experimental pulmonary arterial hypertension.
Basic Res. Cardiol. 110 , 57, (2015) Clinical studies suggest that aerobic exercise can exert beneficial effects in pulmonary arterial hypertension (PAH), but the underlying mechanisms are largely unknown. We compared the impact of early or late aerobic exercise training on right ventricular fun... |