二亚乙基三胺五乙酸二酐
二亚乙基三胺五乙酸二酐结构式
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常用名 | 二亚乙基三胺五乙酸二酐 | 英文名 | DiethylenetriaMinepentaacetic Dianhydride |
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| CAS号 | 23911-26-4 | 分子量 | 357.316 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 656.2±55.0 °C at 760 mmHg | |
| 分子式 | C14H19N3O8 | 熔点 | 182-184 °C(lit.) | |
| MSDS | 中文版 美版 | 闪点 | 350.6±31.5 °C | |
| 符号 |
GHS07 |
信号词 | Warning |
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Self-assembling bubble carriers for oral protein delivery.
Biomaterials 64 , 115-24, (2015) Successful oral delivery of therapeutic proteins such as insulin can greatly improve the quality of life of patients. This study develops a bubble carrier system by loading diethylene triamine pentaacetic acid (DTPA) dianhydride, a foaming agent (sodium bicar... |
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A Hyaluronic Acid-Conjugated Gadolinium Hepatocyte-Specific T1 Contrast Agent for Liver Magnetic Resonance Imaging.
Mol. Imaging Biol. 17 , 497-503, (2015) In this study, we synthesized hyaluronic acid-conjugated gadolinium (HA-diethylene triamine pentaacetic acid (DTPA)-Gd) and evaluated as hepatocyte-specific magnetic resonance imaging (MRI) contrast agent for the diagnosis of hepatic metastasis.We conducted F... |
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A comparison of the cyclic anhydride and mixed anhydride methods for 111In-DTPA chelation to monoclonal antibodies.
Nuklearmedizin. 23(4) , 193-5, (1984) The cyclic anhydride (CA) and the mixed anhydride (MA) of DTPA were synthesized and used to chelate 111In to an antimelanoma monoclonal antibody. The CA and MA methods showed mean labeling efficiencies of 25.7 and 20.5%, respectively (p = NS). The binding eff... |
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Development of radiolabelled albumin microspheres: a comparison of gamma-emitting radioisotopes of iodine (131I) and indium (111In/113mIn).
Int. J. Rad. Appl. Instrum. B 18(7) , 687-94, (1991) Biodegradable albumin microspheres have been prepared incorporating either 131I or 111In/111In. Using cDTPAA/albumin molar ratios of 1, 3 and 10, approx. 0.7, 2.1 and 7 molecules of DTPA could be coupled to an albumin molecule, labelling efficiency being cons... |
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Factors influencing DTPA conjugation with antibodies by cyclic DTPA anhydride.
J. Nucl. Med. 24(12) , 1158-63, (1983) Diethylenetriaminepentaacetic acid (DTPA) was conjugated with a practical concentration (300 micrograms/ml) of antibody to human albumin (Ab) and 1083 17-1A monoclonal colorectal antibody (MAb-17-1A) via an acylation reaction using cyclic DTPA anhydride (cDTP... |
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Relative reactivity of DTPA, immunoreactive antibody-DTPA conjugates, and nonimmunoreactive antibody-DTPA conjugates toward indium-111.
J. Nucl. Med. 26(5) , 482-7, (1985) Anti-human serum albumin antibody (Ab) was reacted with cyclic DTPA dianhydride (cDTPAA) at various cDTPAA/Ab molar ratios between 1 and 40. Using a carrier In titration method for DTPA and DTPA-antibody conjugate (Ab-DTPA), we determined that the above react... |
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Coupling antibody with DTPA--an alternative to the cyclic anhydride.
Int. J. Appl. Radiat. Isot. 35(6) , 554-7, (1984)
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Labeling monoclonal antibodies and F(ab')2 fragments with (111In) indium using cyclic DTPA anhydride and their in vivo behavior in mice bearing human tumor xenografts.
Cancer Drug Deliv. 1(2) , 125-35, (1984) Monoclonal antibodies (MAb) and their F(ab')2 fragments to human colorectal carcinoma (CRC) and human melanoma-associated antigens were conjugated to diethylenetriaminepentaacetic acid (DTPA) via an acylation reaction using cyclic DTPA dianhydride. Relative i... |
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Radiolabelling of monoclonal antibodies: optimization of conjugation of DTPA to F(ab')2-fragments and a novel measurement of the degree of conjugation using Eu(III)-labelling.
Eur. J. Nucl. Med. 15(3) , 157-61, (1989) F(ab')2 fragments (at concentrations of 5-30 mg/ml) derived from monoclonal antibodies raised against human prostate specific acid phosphatase were derivatized with a bicyclic anhydride of diethylenetriaminepentaacetic acid (cDTPAA) in the molar ratios of cDT... |
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Efficient conjugation of DTPA to an IgM monoclonal antibody in ascites fluid.
Int. J. Rad. Appl. Instrum. B 15(3) , 285-92, (1988) We have developed a simple, rapid, and reproducible method for conjugating the bifunctional metal chelator diethylenetriaminepentaacetic acid (DTPA) to an IgM monoclonal antibody (MoAb) without first isolating the MoAb from the ascites fluid. Treatment of the... |