氯氮卓
一般危化品
氯氮卓结构式
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常用名 | 氯氮卓 | 英文名 | chlordiazepoxide |
|---|---|---|---|---|
| CAS号 | 58-25-3 | 分子量 | 299.75500 | |
| 密度 | 1.29g/cm3 | 沸点 | 451ºC at 760mmHg | |
| 分子式 | C16H14ClN3O | 熔点 | 236-236.5ºC | |
| MSDS | N/A | 闪点 | 226.6ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
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Acute tolerance to chlordiazepoxide qualitatively changes the interaction between flumazenil and pregnanolone and not the interaction between flumazenil and midazolam in rhesus monkeys discriminating midazolam.
Eur. J. Pharmacol. 700(1-3) , 159-64, (2013) Benzodiazepines and neuroactive steroids act at distinct binding sites on γ-aminobutyric acid(A) (GABA(A)) receptors where they positively modulate GABA, resulting in similar acute behavioral effects. Tolerance to benzodiazepines can develop with repeated tre... |
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Use of a Sonogel-Carbon electrode modified with bentonite for the determination of diazepam and chlordiazepoxide hydrochloride in tablets and their metabolite oxazepam in urine.
Talanta 89 , 448-54, (2012) Sonogel-Carbon electrode (SngCE) modified with bentonite (BENT) shows an interesting alternative electrode to be used in the determination of 1,4-benzodiazepines by square wave adsorptive cathodic stripping voltammetry (SWAdCSV). Diazepam (DZ) and chlordiazep... |
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[Burning sensation in oral cavity--burning mouth syndrome in everyday medical practice].
Ideggyogy. Sz. 65(9-10) , 295-301, (2012) Burning mouth syndrome (BMS) refers to chronic orofacial pain, unaccompanied by mucosal lesions or other evident clinical signs. It is observed principally in middle-aged patients and postmenopausal women. BMS is characterized by an intense burning or stingin... |
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Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice.
Behav. Brain Res. 228(2) , 351-8, (2012) Catechol-O-methyltransferase, an enzyme involved in regulating brain catecholamine levels, has been implicated in anxiety, pain and/or stress responsivity. Elements of this putative association remain unclarified, notably whether: (a) COMT variation modulates... |
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A double blind randomised comparison of chlordiazepoxide and lorazepam in alcohol withdrawal.
Asian J. Psychiatr. 6(5) , 401-3, (2013) To compare the efficacy of lorazepam and chlordiazepoxide in alcohol withdrawal in a double blind design.The study sample consisted of 108 consecutive admissions to the de addiction ward, which after informed consent and selection based on inclusion criteria,... |
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Benzodiazepine stability in postmortem samples stored at different temperatures.
J. Anal. Toxicol. 36(1) , 52-60, (2012) Benzodiazepine (lorazepam, estazolam, chlordiazepoxide, and ketazolam) stability was studied in postmortem blood, bile, and vitreous humor stored at different temperatures over six months. The influence of NaF, in blood and bile samples, was also investigated... |
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The amphetamine-chlordiazepoxide mixture, a pharmacological screen for mood stabilizers, does not enhance amphetamine-induced disruption of prepulse inhibition.
Behav. Brain Res. 225(1) , 377-81, (2011) In rodents, administration of a mixture of the psychostimulant d-amphetamine and the benzodiazepine chlordiazepoxide results in supra-additive hyperlocomotion, a phenomenon used to identify mood stabilizers. In an attempt to determine whether the d-amphetamin... |
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A clozapine-like effect of cyproheptadine on progressive ratio schedule performance.
J. Psychopharmacol. 26(6) , 857-70, (2012) The atypical antipsychotic drug clozapine has multiple pharmacological actions, some of which, including 5-hydroxytryptamine (5-HT₂) and histamine (H₁) receptor antagonist effects, are shared by the non-selective 5-HT receptor antagonist cyproheptadine. Atypi... |
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K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β.
J. Neurochem. 121(3) , 373-82, (2012) Several metabolic neuroimaging studies have indicated that bipolar patients with mania exhibit alterations in metabolic activity, suggesting that perturbations in corticolimbic function contribute to the functional deficits associated with the disease. Becaus... |
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Mu-opioid receptor knockout mice are more sensitive to chlordiazepoxide-induced anxiolytic behavior.
Brain Res. Bull. 90 , 137-41, (2013) We have previously demonstrated benzodiazepine binding in the cortex and hippocampus of mu-opioid receptor knockout (KO) mice. It is known that benzodiazepine receptors are involved in regulating anxiety-like behaviors. Thus, the present study was designed to... |