R-文拉法辛
R-文拉法辛结构式
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常用名 | R-文拉法辛 | 英文名 | (S)-(−)-Warfarin |
|---|---|---|---|---|
| CAS号 | 5543-58-8 | 分子量 | 308.328 | |
| 密度 | 1.3±0.1 g/cm3 | 沸点 | 515.2±50.0 °C at 760 mmHg | |
| 分子式 | C19H16O4 | 熔点 | ≥170ºC | |
| MSDS | 中文版 美版 | 闪点 | 188.8±23.6 °C | |
| 符号 |
GHS08 |
信号词 | Danger |
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Hologram QSAR model for the prediction of human oral bioavailability.
Bioorg. Med. Chem. 15 , 7738-45, (2007) A drug intended for use in humans should have an ideal balance of pharmacokinetics and safety, as well as potency and selectivity. Unfavorable pharmacokinetics can negatively affect the clinical development of many otherwise promising drug candidates. A varie... |
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Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes.
J. Thromb. Haemost. 8(12) , 2708-17, (2010) Warfarin, an antagonist of vitamin K, is an oral coumarin anticoagulant widely used to control and prevent thromboembolic disorders. Warfarin is clinically available as a racemic mixture of R- and S-warfarin. The S-enantiomer has three to five times greater a... |
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Secreted protein profile from HepG2 cells incubated by S(-) and R(+) enantiomers of chiral drug warfarin - An analysis in cell-based system and clinical samples.
Proteomics. Clin. Appl. 4(10-11) , 808-15, (2010) warfarin is a commonly prescribed oral anticoagulant with narrow therapeutic index. It interferes with the vitamin K cycle to achieve anti-coagulating effects. Warfarin has two enantiomers, S(-) and R(+) and undergoes stereoselective metabolism, with the S(-)... |
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Chemical modification with high molecular weight polyethylene glycol reduces transduction of hepatocytes and increases efficacy of intravenously delivered oncolytic adenovirus.
Hum. Gene Ther. 20(9) , 975-88, (2009) Oncolytic adenoviruses are anticancer agents that replicate within tumors and spread to uninfected tumor cells, amplifying the anticancer effect of initial transduction. We tested whether coating the viral particle with polyethylene glycol (PEG) could reduce ... |
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Studies of imipramine binding to human serum albumin by high-performance affinity chromatography.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 877 , 1149-54, (2009) Binding by the drug imipramine to the protein human serum albumin (HSA) was studied by using high-performance affinity chromatography. The association equilibrium constants and number of binding sites for imipramine with HSA were first estimated by utilizing ... |