N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)
N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂)结构式
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常用名 | N,N-二甲基-D-赤型鞘氨醇(PKC抑制剂) | 英文名 | N,N-Dimethylsphingosine |
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| CAS号 | 119567-63-4 | 分子量 | 327.545 | |
| 密度 | 0.9±0.1 g/cm3 | 沸点 | 447.2±45.0 °C at 760 mmHg | |
| 分子式 | C20H41NO2 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 186.1±27.4 °C |
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Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors.
Am. J. Pathol. 185(2) , 387-98, (2015) Sphingosine 1-phosphate (S1P) is involved in multiple pathological processes, including fibrogenesis. S1P participates in mouse liver fibrogenesis via a paracrine manner. Herein, we investigated the involvement of S1P in human liver fibrosis. Human fibrotic s... |
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Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.
Cancer Res. 51(6) , 1613-8, (1991) Sphingosine (SPN) has been claimed to be a negative modulator of transmembrane signaling through protein kinase C (PK-C) or some yet unidentified mechanism [for review see Y. A. Hannun and R. M. Bell, Science (Washington DC), 243: 500-507, 1989]. N,N-Dimethyl... |
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Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.
Biochem. Pharmacol. 44(8) , 1585-95, (1992) Neutrophils display three major functions: (i) oxidative burst, (ii) phagokinetic activity, and (iii) trans-endothelial migration. Sphingosine (SPN) is known to inhibit oxidative burst in human neutrophils via inhibition of protein kinase C (PKC). SPN is meta... |
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A specific enhancing effect of N,N-dimethylsphingosine on epidermal growth factor receptor autophosphorylation. Demonstration of its endogenous occurrence (and the virtual absence of unsubstituted sphingosine) in human epidermoid carcinoma A431 cells.
J. Biol. Chem. 265 , 5385, (1990) Our previous study suggested that N,N-dimethylsphingosine, but not unsubstituted sphingosine, could be a modulator of protein kinase C in epidermoid carcinoma A431 cells, since N,N-dimethyl-D-erythrosphingenine showed a stronger stereospecific effect on prote... |