N,N-Dimethylsphingosine
N,N-Dimethylsphingosine structure
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Common Name | N,N-Dimethylsphingosine | ||
|---|---|---|---|---|
| CAS Number | 119567-63-4 | Molecular Weight | 327.545 | |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 447.2±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H41NO2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 186.1±27.4 °C | |
Use of N,N-DimethylsphingosineN,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines[1]. |
| Name | N,N-Dimethylsphingosine |
|---|---|
| Synonym | More Synonyms |
| Description | N,N-Dimethylsphingosine is a potent inhbitor of SphK (sphingosine kinase) as an endogenous metabolite of sphingosine produced in various tissues and tumor cell lines[1]. |
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| Related Catalog | |
| References |
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 447.2±45.0 °C at 760 mmHg |
| Molecular Formula | C20H41NO2 |
| Molecular Weight | 327.545 |
| Flash Point | 186.1±27.4 °C |
| Exact Mass | 327.313721 |
| PSA | 43.70000 |
| LogP | 7.64 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.483 |
| InChIKey | YRXOQXUDKDCXME-YIVRLKKSSA-N |
| SMILES | CCCCCCCCCCCCCC=CC(O)C(CO)N(C)C |
| Storage condition | −20°C |
| Hazard Codes | F: Flammable; |
|---|---|
| Risk Phrases | R11 |
| Safety Phrases | S7-S16 |
| RIDADR | UN 1170 3/PG 2 |
| WGK Germany | 1 |
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Intracellular sphingosine 1-phosphate contributes to collagen expression of hepatic myofibroblasts in human liver fibrosis independent of its receptors.
Am. J. Pathol. 185(2) , 387-98, (2015) Sphingosine 1-phosphate (S1P) is involved in multiple pathological processes, including fibrogenesis. S1P participates in mouse liver fibrogenesis via a paracrine manner. Herein, we investigated the i... |
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Cell membrane signaling as target in cancer therapy: inhibitory effect of N,N-dimethyl and N,N,N-trimethyl sphingosine derivatives on in vitro and in vivo growth of human tumor cells in nude mice.
Cancer Res. 51(6) , 1613-8, (1991) Sphingosine (SPN) has been claimed to be a negative modulator of transmembrane signaling through protein kinase C (PK-C) or some yet unidentified mechanism [for review see Y. A. Hannun and R. M. Bell,... |
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Effect of sphingosine and its N-methyl derivatives on oxidative burst, phagokinetic activity, and trans-endothelial migration of human neutrophils.
Biochem. Pharmacol. 44(8) , 1585-95, (1992) Neutrophils display three major functions: (i) oxidative burst, (ii) phagokinetic activity, and (iii) trans-endothelial migration. Sphingosine (SPN) is known to inhibit oxidative burst in human neutro... |
| 4-Octadecene-1,3-diol, 2-(dimethylamino)-, (2S,3R,4E)- |
| 4-Octadecene-1,3-diol, 2-(dimethylamino)-, (R-(R*,S*-(E)))- |
| N,N-Dimethyl-D-erythrosphingenine |
| d-erythro-sphingosine, n,n-dimethyl- |
| (E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol |
| (2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol |
| N,N-Dimethylsphingosine |
| N,N-Dimethyl-D-erythro-Sphingosine |
| (2S,3R,4E)-2-(dimethylamino)octadec-4-ene-1,3-diol |
| MFCD00153960 |