4H-8-溴-1,2,4-噁二唑(3,4-d)苯并(b)(1,4)噁嗪-1-酮
4H-8-溴-1,2,4-噁二唑(3,4-d)苯并(b)(1,4)噁嗪-1-酮结构式
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常用名 | 4H-8-溴-1,2,4-噁二唑(3,4-d)苯并(b)(1,4)噁嗪-1-酮 | 英文名 | NS-2028 |
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| CAS号 | 204326-43-2 | 分子量 | 269.052 | |
| 密度 | 2.1±0.1 g/cm3 | 沸点 | 353.8±52.0 °C at 760 mmHg | |
| 分子式 | C9H5BrN2O3 | 熔点 | 161-162ºC | |
| MSDS | 美版 | 闪点 | 167.8±30.7 °C |
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Contribution of nitric oxide-dependent guanylate cyclase and reactive oxygen species signaling pathways to desensitization of μ-opioid receptors in the rat locus coeruleus.
Neuropharmacology 99 , 422-31, (2015) Nitric oxide (NO) is involved in desensitization of μ-opioid receptors (MOR). We used extracellular recordings in vitro to unmask the NO-dependent pathways involved in MOR desensitization in the rat locus coeruleus (LC). Perfusion with ME (3 and 10 μM) concen... |
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Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase.
Br. J. Pharmacol. 123 , 299-309, (1998) 1 The haeme-containing soluble guanylyl cyclase (alpha1beta1-heterodimer) is a major intracellular receptor and effector for nitric oxide (NO) and carbon monoxide (CO) and mediates many of their biological actions by increasing cyclic GMP. We have synthesized... |
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