3'-去磷酸辅酶 A
3'-去磷酸辅酶 A结构式
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常用名 | 3'-去磷酸辅酶 A | 英文名 | 3'-O-dephosphono-coenzyme A |
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| CAS号 | 3633-59-8 | 分子量 | 687.55400 | |
| 密度 | 1.85±0.1 g/cm3(Predicted) | 沸点 | N/A | |
| 分子式 | C21H35N7O13P2S | 熔点 | N/A | |
| MSDS | 美版 | 闪点 | N/A |
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Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.
Anal. Biochem. 430(2) , 151-5, (2012) We describe here a simultaneous high-performance liquid chromatography method for practical and rapid determination of coenzyme A (CoA), dephospho-CoA, and acetyl-CoA in tissues. These coenzymes are biosynthesized from the vitamin pantothenic acid (PaA), whic... |
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Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.
Biochemistry 39(43) , 13233-40, (2000) Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage to serine 25. We have shown in the preceding paper in this i... |
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Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.
J. Biol. Chem. 274(38) , 27105-11, (1999) Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyrophosphate. Wild-type PPAT from Escherichia coli was purified t... |
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Hydrolysis and absorption of pantothenate and its coenzymes in the rat small intestine.
J. Nutr. 113(10) , 2107-15, (1983) The transport of pantothenate by the rat small intestine occurs by simple diffusion. There was no significant difference in the rate of pantothenate absorption in the upper, middle or lower sections of the intestine. Coenzyme A was hydrolyzed to pantetheine a... |
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Coenzyme A affects firefly luciferase luminescence because it acts as a substrate and not as an allosteric effector.
FEBS J. 272(20) , 5206-16, (2005) The effect of CoA on the characteristic light decay of the firefly luciferase catalysed bioluminescence reaction was studied. At least part of the light decay is due to the luciferase catalysed formation of dehydroluciferyl-adenylate (L-AMP), a by-product tha... |
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Pantothenic acid transport and metabolism in the central nervous system.
Am. J. Physiol. 250(2 Pt 2) , R292-7, (1986) The mechanisms by which pantothenic acid (PA) enters and leaves brain, choroid plexus, and cerebrospinal fluid (CSF) were investigated by injecting [3H]PA either intravenously or intraventricularly into adult rabbits. [3H]PA, either alone or together with unl... |
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Role of active site binding interactions in 4-chlorobenzoyl-coenzyme A dehalogenase catalysis.
Biochemistry 40(51) , 15684-92, (2001) 4-Chlorobenzoyl-coenzyme A (4-CBA-CoA) dehalogenase catalyzes the hydrolytic dehalogenation of 4-CBA-CoA to 4-hydroxybenzoyl-CoA (4-HBA-CoA) via a multistep mechanism involving initial attack of Asp145 on C(4) of the substrate benzoyl ring to form a Meisenhei... |
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Substrate activation by acyl-CoA dehydrogenases: transition-state stabilization and pKs of involved functional groups.
Biochemistry 37(7) , 1848-60, (1998) The mechanism by which acyl-CoA dehydrogenases initiate catalysis was studied by using p-substituted phenylacetyl-CoAs (substituents-NO2, -CN, and CH3CO-), 3S-C8-, and 3'-dephospho-3S-C8CoA. These analogues lack a beta C-H and cannot undergo alpha,beta-dehydr... |
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Kinetic, Thermodynamic, and Structural Insight into the Mechanism of Phosphopantetheine Adenylyltransferase fromMycobacterium tuberculosis
J. Mol. Biol. 404(2) , 202-19, (2010) Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in the coenzyme A (CoA) biosynthetic pathway, reversibly transferring an adenylyl group from ATP to 4′-phosphopantetheine (PhP) to form dephosphocoenzyme A. This reaction sits at the... |
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Hepatic CoA, S-acyl-CoA, biosynthetic precursors of the coenzyme and pantothenate-protein complexes in dietary pantothenic acid deficiency.
Int. J. Vitam. Nutr. Res. 57(1) , 71-7, (1987) Weanling rats were fed a pantothenic acid (PA)-free diet for 11 days. Although the animals did not show symptoms of vitamin deficiency, the concentrations of total and free CoA (analyzed with 2-oxoglutarate dehydrogenase), the levels of CoA, dephospho-CoA and... |