Platensimycin
Platensimycin结构式
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常用名 | Platensimycin | 英文名 | Platensimycin |
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| CAS号 | 835876-32-9 | 分子量 | 441.474 | |
| 密度 | 1.5±0.1 g/cm3 | 沸点 | 683.1±55.0 °C at 760 mmHg | |
| 分子式 | C24H27NO7 | 熔点 | N/A | |
| MSDS | 中文版 美版 | 闪点 | 366.9±31.5 °C |
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FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.
Antimicrob. Agents Chemother. 59(2) , 849-58, (2015) Delineating the mechanisms for genetically acquired antibiotic resistance is a robust approach to target validation and anticipates the evolution of clinical drug resistance. This study defines a spectrum of mutations in fabH that render Staphylococcus aureus... |
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Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.
J. Cell Biol. 203(6) , 985-1001, (2013) Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatty acids to characterize the initial steps of LD formation o... |
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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.
Proc. Natl. Acad. Sci. U. S. A. 108 , 5378-5383, (2011) Platensimycin (PTM) is a recently discovered broad-spectrum antibiotic produced by Streptomyces platensis. It acts by selectively inhibiting the elongation-condensing enzyme FabF of the fatty acid biosynthesis pathway in bacteria. We report here that PTM is a... |
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The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae.
J. Bacteriol. 185 , 4136-4143, (2003) The beta-ketoacyl-acyl carrier protein synthases are members of the thiolase superfamily and are key regulators of bacterial fatty acid synthesis. As essential components of the bacterial lipid metabolic pathway, they are an attractive target for antibacteria... |
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Membrane Affinity of Platensimycin and Its Dialkylamine Analogs.
Int. J. Mol. Sci. 16 , 17909-32, (2015) Membrane permeability is a desired property in drug design, but there have been difficulties in quantifying the direct drug partitioning into native membranes. Platensimycin (PL) is a new promising antibiotic whose biosynthetic production is costly. Six dialk... |