Platensimycin

更新时间：2024-01-02 20:53:25

Platensimycin结构式	常用名	Platensimycin	英文名	Platensimycin
	CAS号	835876-32-9	分子量	441.474
	密度	1.5±0.1 g/cm3	沸点	683.1±55.0 °C at 760 mmHg
	分子式	C₂₄H₂₇NO₇	熔点	N/A
	MSDS	中文版美版	闪点	366.9±31.5 °C

Platensimycin用途

本网站展示的所有产品仅用作科学研究，不可食用，不可用于人体或动物的临床诊断和治疗。

血小板霉素(platensmycin)是一种由S.platensis产生的抗生素,它通过选择性抑制细胞脂质合成(IC50=0.1μM)来抑制革兰氏阳性菌。铂霉素靶向β-酮酰酰基载体蛋白合成酶I/II,FabF/B,一种参与脂肪酸生物合成的酶(金黄色葡萄球菌和大肠杆菌的IC50s分别为48 nM和160 nM)。血小板霉素是一种很有前途的抗药性药物。

中文名	板霉素
英文名	platensimycin
英文别名	更多

描述	血小板霉素(platensmycin)是一种由S.platensis产生的抗生素,它通过选择性抑制细胞脂质合成(IC50=0.1μM)来抑制革兰氏阳性菌。铂霉素靶向β-酮酰酰基载体蛋白合成酶I/II,FabF/B,一种参与脂肪酸生物合成的酶(金黄色葡萄球菌和大肠杆菌的IC50s分别为48 nM和160 nM)。血小板霉素是一种很有前途的抗药性药物。
相关类别	信号通路 >> 抗感染 >> 细菌

密度	1.5±0.1 g/cm3
沸点	683.1±55.0 °C at 760 mmHg
分子式	C₂₄H₂₇NO₇
分子量	441.474
闪点	366.9±31.5 °C
精确质量	441.178741
PSA	136.65000
LogP	3.00
蒸汽压	0.0±2.2 mmHg at 25°C
折射率	1.670
储存条件	-20°C，密闭，干燥

危险品运输编码	NONH for all modes of transport

FabH mutations confer resistance to FabF-directed antibiotics in Staphylococcus aureus.

Antimicrob. Agents Chemother. 59(2) , 849-58, (2015)

Delineating the mechanisms for genetically acquired antibiotic resistance is a robust approach to target validation and anticipates the evolution of clinical drug resistance. This study defines a spec...

Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains.

J. Cell Biol. 203(6) , 985-1001, (2013)

Control of lipid droplet (LD) nucleation and copy number are critical, yet poorly understood, processes. We use model peptides that shift from the endoplasmic reticulum (ER) to LDs in response to fatt...

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes.

Proc. Natl. Acad. Sci. U. S. A. 108 , 5378-5383, (2011)

Platensimycin (PTM) is a recently discovered broad-spectrum antibiotic produced by Streptomyces platensis. It acts by selectively inhibiting the elongation-condensing enzyme FabF of the fatty acid bio...

Benzoic acid, 3-[[3-[(1S,3S,4S,5aS,9S,9aR)-1,4,5,8,9,9a-hexahydro-3,9-dimethyl-8-oxo-3H-1,4:3,5a-dimethano-2-benzoxepin-9-yl]-1-oxopropyl]amino]-2,4-dihydroxy-

3-({3-[(1S,4aS,6S,7S,9S,9aR)-1,6-dimethyl-2-oxo-1,2,5,6,7,8,9,9a-octahydro-6,9-epoxy-4a,7-methanobenzo[7]annulen-1-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid

Platensimycin

3-({3-[(1S,5S,6R,7S,9S,10S)-5,9-Dimethyl-4-oxo-8-oxatetracyclo[7.2.1.1.0]tridec-2-en-5-yl]propanoyl}amino)-2,4-dihydroxybenzoic acid